Obesity Surgery

, Volume 19, Issue 2, pp 190–195 | Cite as

Bariatric Surgery Improves Atherogenic LDL Profile by Triglyceride Reduction

  • Sabina ZambonEmail author
  • Giovanna Romanato
  • Giovanni Sartore
  • Raffaella Marin
  • Luca Busetto
  • Silvia Zanoni
  • Franco Favretti
  • Giuseppe Sergi
  • Paola Fioretto
  • Enzo Manzato
Research Article



Small dense low-density lipoprotein (LDL) are atherogenic particles frequently observed in obese patients. Fatty acids modulate LDL. Objective of this study was to determine the relations between plasma phospholipid fatty acid composition and the presence of small dense LDL particles in morbidly obese patients treated with laparoscopic gastric banding (LAGB).


Small dense LDL, plasma lipids, lipoproteins, apoproteins, and phospholipid fatty acid composition (a marker of dietary fatty acid intake) were quantified before and 12 months after surgery in four men and 11 women who were morbidly obese and (BMI > 40 kg/m2) eligible for surgery, consecutively treated with LAGB at the Department of Medical and Surgical Sciences of the University of Padova.


BMI was 48.3 ± 4.8 kg/m2 before and 36.1 ± 5.5 kg/m2 after LAGB. Plasma triglycerides and apoprotein E levels significantly decreased, while HDL cholesterol significantly increased after LAGB. A reduction of small dense LDL with an increase of LDL relative flotation (0.34 ± 0.04 before vs 0.38 ± 0.03 after LAGB, p < 0.001) was also observed. These modifications were neither related to weight reduction nor to changes in phospholipid fatty acid composition, but they were associated to triglyceride reduction, which explained 76.7% of the LDL relative flotation variation.


Weight loss obtained by LAGB in morbidly obese subjects was accompanied by triglyceride reduction, high-density lipoprotein increase, and an improvement of the atherogenic LDL profile. Triglyceride reduction, but not the extent of weight loss or dietary fatty acid modifications, is the determinant of modifications of LDL physical properties in these patients.


Obesity Bariatric surgery Lipids Fatty acids Small dense LDL 


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Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • Sabina Zambon
    • 1
    Email author
  • Giovanna Romanato
    • 1
  • Giovanni Sartore
    • 1
  • Raffaella Marin
    • 1
  • Luca Busetto
    • 1
  • Silvia Zanoni
    • 1
  • Franco Favretti
    • 2
  • Giuseppe Sergi
    • 1
  • Paola Fioretto
    • 1
  • Enzo Manzato
    • 3
  1. 1.Department of Medical and Surgical SciencesUniversity of PadovaPadovaItaly
  2. 2.Department of SurgeryRegional Hospital of VicenzaVicenzaItaly
  3. 3.Department of Medical and Surgical SciencesUniversity of Padova, and CNR Institute of Neurosciences, Center on AgingPadovaItaly

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