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Obesity Surgery

, Volume 19, Issue 6, pp 745–750 | Cite as

In Morbid Obesity, Metabolic Abnormalities and Adhesion Molecules Correlate with Visceral Fat, Not with Subcutaneous Fat: Effect of Weight Loss Through Surgery

  • Antonio E. Pontiroli
  • Francesca Frigè
  • Michele Paganelli
  • Franco Folli
Research Article

Abstract

Background

Decrease of both visceral fat (surgery, physical exercise) and subcutaneous fat (liposuction) is accompanied by improvement of insulin sensitivity.

Methods

In this study, metabolic variables (glucose, insulin, high-density lipoprotein–cholesterol, triglycerides, aspartate aminotransferase, alanine aminotransferase, uric acid, ferritin) and adhesion molecules (ICAM-1, entothelin-1, E-selectin) were determined in 126 morbidly obese subjects before and 1 year after bariatric restrictive surgery (laparoscopic gastric banding) and correlated with anthropometric measures, i.e., body mass index (BMI) and waist circumference (waist), and with echographic measures of thickness of visceral (usVT) and subcutaneous (usST) abdominal fat.

Results

Under basal conditions and after 1 year, metabolic variables correlated with BMI and waist (r from 0.157 to 0.507, p from 0.0182 to 0.0001) and with usVT (r from 0.211 to 0.512, p from 0.05 to 0.0001); insulin also correlated with usST, and adhesion molecules only correlated with BMI and usVT (r from 0.341 to 0.502, p from 0.0066 to 0.0001). Changes of metabolic variables correlated with changes of BMI and waist (r from 0.163 to 0.356, p from 0.0328 to 0.0001) and with usVT changes (r from 0.211 to 0.361, p from 0.0339 to 0.0002); changes of adhesion molecules only correlated with BMI and usVT changes (r from 0.227 to 0.361, p from 0.0444 to 0.0108). Changes of metabolic variables and of adhesion molecules virtually never correlated with changes of usST.

Conclusion

These data indicate that in morbid obesity, most metabolic abnormalities are associated with visceral fat and that their improvements after weight loss are associated with decrease of visceral fat.

Keywords

Visceral fat Obesity Gastric banding Adhesion molecules Metabolic syndrome 

Notes

Acknowledgments

This work was supported by Grant FIRST 2006 from Universita’ degli Studi di Milano.

Disclosures

The authors of this manuscript have no potential conflicts of interest.

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Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • Antonio E. Pontiroli
    • 1
  • Francesca Frigè
    • 1
  • Michele Paganelli
    • 2
  • Franco Folli
    • 3
  1. 1.Ospedale San PaoloUniversità degli Studi di MilanoMilanItaly
  2. 2.Ospedale San RaffaeleMilanItaly
  3. 3.University of Texas Health Science Center at San AntonioSan AntonioUSA

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