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Obesity Surgery

, Volume 19, Issue 7, pp 879–882 | Cite as

Hypocarotenemia After Bariatric Surgery: A Preliminary Study

  • F. Granado-LorencioEmail author
  • C. Herrero-Barbudo
  • B. Olmedilla-Alonso
  • I. Blanco-Navarro
  • B. Pérez-Sacristán
Original Article

Abstract

Background

Dietary carotenoids have attracted a great deal of attention due to their potential clinical relevance in conditions such as age-related maculopathy, osteoporosis, cardiovascular disease, and cancer. Surgical procedures have become the primary treatment of severe obesity, although nutrient deficiencies are common and long-term metabolic sequelae remain unknown. Thus, our aim was to assess the carotenoid status in serum of subjects after obesity surgery.

Methods

We evaluated the status of lutein, zeaxanthin, α- and β-cryptoxanthin, lycopene, α- and β-carotene, and fat-soluble vitamins by a quality-controlled high-performance liquid chromatography method in serum of 53 patients. Subjects were consecutively included as they were monitored for nutritional status after Roux-en-Y gastric bypass (RYGBP) or biliopancreatic diversion (BPD). Average follow-up time was 18 and 14 months for each protocol, respectively.

Results

After obesity surgery, a consistent and continuous decline in all carotenoids to almost undetectable levels occurs, especially in those who underwent BPD diversion who, on average, displayed serum levels about one half to one third of those found in RYGBP patients.

Conclusion

The hypocarotenemia observed after bariatric surgery may compromise the availability of carotenoids to tissues and the vitamin A status, reducing the fat-soluble antioxidant capacity and constituting an additional risk factor for several clinical conditions. Given the emerging role of carotenoids in disease prevention, dietary advice on carotenoid-rich and fortified foods or the use of supplements in these patients should be considered.

Keywords

Obesity surgery Lutein β-cryptoxanthin β-carotene Lycopene Fat-soluble vitamins 

Notes

Acknowlegdments

The authors are indebted to Martha Messman for preparing the manuscript.

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Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • F. Granado-Lorencio
    • 1
    Email author
  • C. Herrero-Barbudo
    • 1
  • B. Olmedilla-Alonso
    • 2
  • I. Blanco-Navarro
    • 1
  • B. Pérez-Sacristán
    • 1
  1. 1.Unidad de Vitaminas, Servicio de Bioquímica ClínicaHospital Universitario Puerta de HierroMadridSpain
  2. 2.Instituto del Frío-CSICCiudad UniversitariaMadridSpain

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