Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model

  • Hanyu Zhu
  • Bo Fu
  • Yong WangEmail author
  • Jing Gao
  • Qiuxia Han
  • Wenjia Geng
  • Xiaoli Yang
  • Guangyan Cai
  • Xiangmei Chen
  • Dong ZhangEmail author
Research Article


This study aimed to compare clinical features between membranous nephropathy (MN) and nonmembranous nephropathy (non-MN), to explore the clinically differential diagnosis of these two types, and to establish a diagnostic model of MN. After renal biopsy was obtained, 798 patients were divided into two groups based on their examination results: primary MN group (n = 248) and non-MN group (n = 550). Their data were statistically analyzed. Logistic regression analysis indicated that anti-PLA2R antibodies, IgG, and Cr were independently correlated with MN, and these three parameters were then used to establish the MN diagnostic model. A receiver operating characteristic (ROC) curve confirmed that our diagnostic model could distinguish between patients with and without MN, and their corresponding sensitivity, specificity, and AUC were 79.9%, 89.4%, and 0.917, respectively. The cutoff value for this combination in MN diagnosis was 0.34. The established diagnostic model that combined multiple factors shows a potential for broad clinical applications in differentiating primary MN from other kidney diseases and provides reliable evidence supporting the feasibility of noninvasive diagnosis of kidney diseases.


multiparameter analysis diagnosis model membranous nephropathy 


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This study was supported by (1) National Key R&D Program of China (No. 2016YFC1305500), (2) the National Natural Science Foundation of China (Nos. 61471399 and 61671479), (3) Innovation Nursery Fund of PLA General Hospital (No. 15KMZ04), and (4) the National Natural Science Foundation of China (No. 81401719).


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Copyright information

© Higher Education Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Hanyu Zhu
    • 1
  • Bo Fu
    • 1
  • Yong Wang
    • 1
    Email author
  • Jing Gao
    • 2
  • Qiuxia Han
    • 3
  • Wenjia Geng
    • 1
  • Xiaoli Yang
    • 1
  • Guangyan Cai
    • 1
  • Xiangmei Chen
    • 1
  • Dong Zhang
    • 1
    Email author
  1. 1.Department of NephrologyChinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing Key Laboratory of Kidney DiseaseBeijingChina
  2. 2.Department of Clinical BiochemistryChinese PLA General HospitalBeijingChina
  3. 3.Department of NephrologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

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