Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model
- 23 Downloads
This study aimed to compare clinical features between membranous nephropathy (MN) and nonmembranous nephropathy (non-MN), to explore the clinically differential diagnosis of these two types, and to establish a diagnostic model of MN. After renal biopsy was obtained, 798 patients were divided into two groups based on their examination results: primary MN group (n = 248) and non-MN group (n = 550). Their data were statistically analyzed. Logistic regression analysis indicated that anti-PLA2R antibodies, IgG, and Cr were independently correlated with MN, and these three parameters were then used to establish the MN diagnostic model. A receiver operating characteristic (ROC) curve confirmed that our diagnostic model could distinguish between patients with and without MN, and their corresponding sensitivity, specificity, and AUC were 79.9%, 89.4%, and 0.917, respectively. The cutoff value for this combination in MN diagnosis was 0.34. The established diagnostic model that combined multiple factors shows a potential for broad clinical applications in differentiating primary MN from other kidney diseases and provides reliable evidence supporting the feasibility of noninvasive diagnosis of kidney diseases.
Keywordsmultiparameter analysis diagnosis model membranous nephropathy
Unable to display preview. Download preview PDF.
This study was supported by (1) National Key R&D Program of China (No. 2016YFC1305500), (2) the National Natural Science Foundation of China (Nos. 61471399 and 61671479), (3) Innovation Nursery Fund of PLA General Hospital (No. 15KMZ04), and (4) the National Natural Science Foundation of China (No. 81401719).
- 8.Wu X, Wen S, Zhu X, Yuan S, Xu X, Yang D, Sun L, Liu H, Liu F. Diagnostic value of renal phospholipase A2 receptor and serum antiphospholipase A2 receptor antibody in membranous nephropathy. Med J Cent South Univ (Zhong Nan Da Xue Xue Bao Yi Xue Ban) 2017; 42(4): 395–399 (in Chinese)Google Scholar
- 11.Iwakura T, Fujigaki Y, Katahashi N, Sato T, Ishigaki S, Tsuji N, Naito Y, Isobe S, Ono M, Sakao Y, Tsuji T, Ohashi N, Kato A, Miyajima H, Yasuda H. Membranous nephropathy with an enhanced granular expression of thrombospondin type-1 domaincontaining 7A in a pregnant woman. Intern Med 2016; 55(18): 2663–2668CrossRefPubMedGoogle Scholar
- 18.Dähnrich C, Komorowski L, Probst C, Seitz-Polski B, Esnault V, Wetzels JF, Hofstra JM, Hoxha E, Stahl RA, Lambeau G, Stöcker W, Schlumberger W. Development of a standardized ELISA for the determination of autoantibodies against human M-type phospholipase A2 receptor in primary membranous nephropathy. Clin Chim Acta 2013; 421(11): 213–218CrossRefPubMedGoogle Scholar
- 19.Quintana LF, Blasco M, Seras M, Pérez NS, López-Hoyos M, Villarroel P, Rodrigo E, Viñas O, Ercilla G, Diekmann F, Gómez-Roman JJ, Fernandez-Fresnedo G, Oppenheimer F, Arias M, Campistol JM. Antiphospholipase A2 receptor antibody levels predict the risk of posttransplantation recurrence of membranous nephropathy. Transplantation 2015; 99(8): 1709–1714CrossRefPubMedGoogle Scholar
- 24.Gu QH, Cui Z, Huang J, Zhang YM, Qu Z, Wang F, Wang X, Wang SX, Liu G, Zhao MH. Patients with combined membranous nephropathy and focal segmental glomerulosclerosis have comparable clinical and autoantibody profiles with primary membranous nephropathy: a retrospective observational study. Medicine (Baltimore) 2016; 95(21): e3786CrossRefGoogle Scholar
- 28.Togo K, Ueo T, Yonemasu H, Honda H, Ishida T, Tanabe H, Yao K, Iwashita A, Murakami K. Two cases of adenocarcinoma occurring in sporadic fundic gland polyps observed by magnifying endoscopy with narrow band imaging. World J Gastroenterol 2016; 22(40): 9028–9034CrossRefPubMedPubMedCentralGoogle Scholar
- 29.Tabata N, Sueta D, Akasaka T, Arima Y, Sakamoto K, Yamamoto E, Izumiya Y, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Morita K, Oniki K, Saruwatari J, Nakagawa K, Hokimoto S. Helicobacter pylori seropositivity in patients with interleukin-1 polymorphisms is significantly associated with ST-segment elevation myocardial infarction. PLoS One 2016; 11(11): e0166240CrossRefPubMedPubMedCentralGoogle Scholar
- 31.Bastard JP, Fellahi S, Lescure FX, Capeau J, Ronco P, Plaisier E. Interest of the combined measurement of selected urinary proteins in the diagnosis approach in nephrology. Ann Biol Clin (Paris) 2017; 75(3): 327–333Google Scholar