DNA methylation-based subclassification of psoriasis in the Chinese Han population

  • Fusheng Zhou
  • Changbing Shen
  • Yi-Hsiang Hsu
  • Jing Gao
  • Jinfa Dou
  • Randy Ko
  • Xiaodong Zheng
  • Liangdan Sun
  • Yong Cui
  • Xuejun Zhang
Research Article
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Abstract

Psoriasis (Ps) is an inflammatory skin disease caused by genetic and environmental factors. Previous studies on DNA methylation (DNAm) found genetic markers that are closely associated with Ps, and evidence has shown that DNAm mediates genetic risk in Ps. In this study, Consensus Clustering was used to analyze DNAm data, and 114 Ps patients were divided into three subclassifications. Investigation of the clinical characteristics and copy number variations (CNVs) of DEFB4, IL22, and LCE3C in the three subclassifications revealed no significant differences in gender ratio and in Ps area and severity index (PASI) score. The proportion of late-onset ( ⩾ 40 years) Ps patients was significantly higher in type I than in types II and III (P = 0.035). Type III contained the smallest proportion of smokers and the largest proportion of non-smoking Ps patients (P = 0.086). The CNVs of DEFB4 and LCE3C showed no significant differences but the CNV of IL22 significantly differed among the three subclassifications (P = 0.044). This study is the first to profile Ps subclassifications based on DNAm data in the Chinese Han population. These results are useful in the treatment and management of Ps from the molecular and genetic perspectives.

Keywords

psoriasis DNA methylation subclassification 

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Notes

Acknowledgements

This project was mainly supported by the National Natural Science Foundation of China (No. 81502713), Grants for Scientific Research of BSKY (No. XJ201634) from Anhui Medical University, and Key Program of Outstanding Talents of Anhui Province (No. gxyqZD2017028). We are grateful to all the participants involved in this study.

Supplementary material

11684_2017_588_MOESM1_ESM.pdf (446 kb)
FMD-17073-ZFS (FMD-2017-0100) Supplementary Material

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Copyright information

© Higher Education Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Fusheng Zhou
    • 1
    • 2
    • 3
  • Changbing Shen
    • 4
    • 5
    • 6
    • 7
    • 8
  • Yi-Hsiang Hsu
    • 7
    • 8
    • 9
  • Jing Gao
    • 10
  • Jinfa Dou
    • 1
    • 2
    • 3
    • 6
  • Randy Ko
    • 11
  • Xiaodong Zheng
    • 1
    • 2
    • 3
    • 6
  • Liangdan Sun
    • 1
    • 2
    • 3
    • 6
  • Yong Cui
    • 4
    • 5
  • Xuejun Zhang
    • 1
    • 2
    • 3
    • 6
    • 10
  1. 1.Institute of Dermatology, The First Affiliated HospitalAnhui Medical UniversityHefeiChina
  2. 2.The Key Laboratory of Dermatology (Anhui Medical University)Ministry of EducationHefeiChina
  3. 3.Collaborative Innovation Center for Complex and Severe DermatosisAnhui Medical UniversityHefeiChina
  4. 4.Department of DermatologyChina-Japan Friendship HospitalBeijingChina
  5. 5.Graduate SchoolPeking Union Medical College and Chinese Academy of Medical SciencesBeijingChina
  6. 6.Department of Dermatology, The First Affiliated HospitalAnhui Medical UniversityHefeiChina
  7. 7.Molecular and Integrative Physiological Sciences, Harvard T.H.CHAN School of Public HealthBostonUSA
  8. 8.Hebrew SeniorLife Institute for Aging Research and Harvard Medical SchoolBostonUSA
  9. 9.Broad Institute of MIT and HarvardCambridgeUSA
  10. 10.Department of Dermatology, The Second Affiliated HospitalAnhui Medical UniversityHefeiChina
  11. 11.Department of BiochemistryUniversity of New MexicoAlbuquerqueUSA

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