Chemotherapy-induced brain changes in breast cancer survivors: evaluation with multimodality magnetic resonance imaging

  • Yun Feng
  • Xiao Dong Zhang
  • Gang Zheng
  • Long Jiang ZhangEmail author


Chemotherapy related cognitive impairments are common in breast cancer patients undergoing chemotherapy. These cognitive dysfunctions are mainly attributable to chemotherapy related brain structural and functional alterations. Multimodality magnetic resonance imaging (MRI) can reveal brain gray matter volume loss, white matter microstructural disruption, reduced gray matter density, impaired cerebral blood flow and brain structural and functional connection networks at both local and global levels. This review outlines the potential applications of multimodality MR imaging techniques in chemotherapy induced cognitive deficit in breast cancer survivors and provides future research perspective in this field.


Functional magnetic resonance imaging Cognitive impairment Breast cancer Chemotherapy MR imaging techniques 



Magnetic resonance imaging


Blood oxygen level dependent


Functional MRI


Voxel-based morphological


Diffusion tensor imaging


Arterial spin labeling


Chemotherapy related cognitive impairment


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval and informed consent

This is a review article and therefore does not contain any new data from studies with human participants or animals performed by any of the authors.

Supplementary material

11682_2019_74_MOESM1_ESM.docx (30 kb)
ESM 1 (DOCX 29.9 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Yun Feng
    • 1
    • 2
  • Xiao Dong Zhang
    • 3
  • Gang Zheng
    • 1
    • 4
  • Long Jiang Zhang
    • 1
    • 5
    Email author
  1. 1.Department of Medical Imaging, Jinling HospitalNanjing Medical UniversityNanjingChina
  2. 2.Department of Medical ImagingThe Affiliated Huaian No.1 People’s Hospital of Nanjing Medical UniversityHuaianChina
  3. 3.Department of RadiologyTianjin First Central HospitalTianjinChina
  4. 4.Monash Biomedical ImagingMonash UniversityClaytonAustralia
  5. 5.Department of Medical Imaging, Jinling HospitalMedical School of Nanjing UniversityNanjingChina

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