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Postchemotherapy hippocampal functional connectivity patterns in patients with breast cancer: a longitudinal resting state functional MR imaging study

  • Yun Feng
  • Dilihumaer Tuluhong
  • Zhao Shi
  • Li Juan Zheng
  • Tao Chen
  • Guang Ming Lu
  • Shaohua WangEmail author
  • Long Jiang ZhangEmail author
ORIGINAL RESEARCH

Abstract

The hippocampus plays a key role in cognitive function and emotion regulation due to its wide connection with the whole brain. This study examined the acute effect of chemotherapy on hippocampal and subfield functional connectivity and neuropsychological status in breast cancer patients (BC). This IRB approved study included 29 BC and 25 age matched healthy controls (HCs) who underwent resting state functional magnetic resonance imaging (Rs-fMRI), neuropsychological tests and blood examinations at baseline and one week after completing chemotherapy or in the same time interval. Within-group comparisons and group-by-time interactions analysis of hippocampus- and subregion- based functional connectivity were performed between the two groups. Functional connectivity changes were correlated with changes of blood examination and neuropsychological test scores in the BC group. The BC group had higher depression and anxiety scores, poorer performance on visual mobility, auditory memory and executive function than HCs (p < 0.05), and significantly abnormal estrodiol, total cholesterol and triglycerides (p < 0.05). BC survivors showed significant hippocampal functional connectivity changes mainly in the left insula, temporal lobe (Gaussian Random Field theory correction, P < 0.001) and the left inferior frontal gyrus (P < 0.01). The functional connections from the anterior hippocampus to the left temporal lobe were greater than the posterior hippocampus (P < 0.05). The hippocampus functional connectivity alterations were closely related to changes in depression scores, estrodiol and triglycerides (all p < 0.05). Chemotherapy induced especially anterior hippocampal functional connectivity abnormality, which is related to depression symptom, estrodiol and triglycerides disorders.

Keywords

Breast cancer Chemotherapy Hippocampus Functional connectivity Resting state functional magnetic resonance imaging 

Notes

Funding

This study was supported by the grants from the Natural Scientific Foundation of China (81322020 and 81230032 to L.J.Z.).

Compliance and ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All the procedures involving human subjects were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

We confirm that informed consent was obtained from all the participants included in this study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Yun Feng
    • 1
    • 2
  • Dilihumaer Tuluhong
    • 3
  • Zhao Shi
    • 4
  • Li Juan Zheng
    • 4
  • Tao Chen
    • 3
  • Guang Ming Lu
    • 4
  • Shaohua Wang
    • 3
    Email author
  • Long Jiang Zhang
    • 1
    • 4
    Email author
  1. 1.Department of Medical ImagingJinling Hospital,Nanjing Medical UniversityNanjingChina
  2. 2.Department of Medical Imaging, Medical Imaging CenterThe Affiliated Huaian No.1 People’s Hospital of Nanjing Medical UniversityHuai’ anChina
  3. 3.Department of General Surgery, Jinling HospitalMedical School of Nanjing UniversityNanjingPeople’s Republic of China
  4. 4.Department of Medical Imaging, Jinling HospitalMedical School of Nanjing UniversityNanjingChina

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