Amygdala network in response to facial expression following neurofeedback training of emotion
Real-time functional magnetic resonance imaging (rtfMRI) has been applied to self-regulate activity in the amygdala and improve emotional perception and recognition as a novel neurofeedback training method. Previous studies have indicated that successful regulation of the target region led to changes in other brain regions as a network during neurofeedback training. However, it is unclear how neurofeedback training of the amygdala affects the network engaged in facial expression. In this study, we investigated the changes in the amygdala network involved in a facial expression task after rtfMRI training of the left amygdala. The amygdala network of pre- and post-training tasks with pleasant expression as the stimulus was extracted using group independent component analysis. The results showed that not only the activity of the amygdala network but also the functional connectivity of the fusiform with the amygdala within the network was enhanced by training. Moreover, increases in this connectivity were correlated with increases in behavioral performance. These findings suggest the functional significance of the connectivity of the fusiform with the amygdala engaged in facial emotional perception as well as their close correlation with behavior, thus providing new insights into the mechanisms of neurofeedback-based emotional regulation and clinical treatment of related emotional disorders.
KeywordsAmygdala network Neurofeedback Facial expression Independent component analysis Emotional regulation
This study was funded by the Funds for National Natural Science Foundation of China (grant number 61473044, 61871040) and the Key Program of National Natural Science Foundation of China (grant number 61731003, 61431002).
Compliance with ethical standards
Conflict of interest
All authors declare that he/she has no conflict of interest.
All procedures performed in studies involving human subjects were in accordance with the ethical standards of the Institutional Review Board of the State Key Laboratory of Cognitive Neuroscience and Learning at Beijing Normal University and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual subjects included in the study.
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