Active information storage in Parkinson’s disease: a resting state fMRI study over the sensorimotor cortex

  • Aura Cristina Puche SarmientoEmail author
  • Yamile Bocanegra García
  • John Fredy Ochoa Gómez


Parkinson’s disease (PD), the second most frequent neurodegenerative disease, affects significantly life quality by a combination of motor and cognitive disturbances. Although it is traditionally associated with basal ganglia dysfunction, cortical alterations are also involved in disease symptoms. Our objective is to evaluate the alterations in brain dynamics in de novo and recently treated PD subjects using a nonlinear method known as Active Information Storage. In the current research, Active Information Storage (AIS) was used to study the complex dynamics in motor cortex spontaneous activity captured using resting state functional Magnetic Resonance Imaging (rs-fMRI) at early-stage in non-medicated and recently medicated PD subjects. Supplementary to AIS, the fractional Amplitude of Low Frequency Fluctuation (fALFF), which is a better-established technique of analysis of rs-fMRI signals, was also evaluated. Compared to healthy subjects, the AIS values were significantly reduced in PD patients over the analyzed motor cortex regions; differences were also found at less extent using the fALFF measure. Correlations between AIS and fALFF values showed that the measures seem to capture similar neuronal phenomena in rs-fMRI data. The highest sensitivity when detecting group differences revealed by AIS, and not captured by traditional linear approaches, suggests that this measure is a promising tool for the analysis of rs-fMRI neural data in PD.


Parkinson’s disease Active information storage Resting-state functional magnetic resonance imaging Fractional amplitude of low frequency fluctuation Motor cortex 



The research over the data was supported by Vicerrectoría de Investigación de la Universidad de Antioquia (CODI), project “Neurofisiología y Neuropsicología en Enfermedad Ganglio Basal”, code PRG2014-768. Data used in the preparation of this article were obtained from the Parkinson’s Progression Markers Initiative (PPMI) database ( For up-to-date information on the study, visit PPMI – a public-private partnership –funded by the Michael J. Fox Foundation for Parkinson’s Research and funding partners, including Abbvie, Avid Radiopharmaceuticals, Biogen, BioLegend, Bristol-Myers Squibb, General Electric Healthcare, Genentech, GlaxoSmithKline, Lilly, Lundbeck, Merck, Meso Scale Discovery, Pfizer, Piramal Imaging, Roche, Sanofi-Genzyme, Servier, Takeda, Teva and UCB.


This study was funded by the Universidad de Antioquia under the code PRG2014–768.

Compliance with ethical standards

Conflict of interest

The authors declare no competing financial interests.

Ethical approval

All procedures performed in studies involving human participants were in accordance with ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained by The PPMI from all individual participants included in the study.

Supplementary material

11682_2019_37_MOESM1_ESM.docx (17 kb)
ESM 1 (DOCX 17 kb)
11682_2019_37_MOESM2_ESM.docx (19 kb)
ESM 2 (DOCX 19 kb)


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Authors and Affiliations

  1. 1.Grupo de Investigación en Bioinstrumentación e Ingeniería Clínica, Facultad de IngenieríaUniversidad de Antioquia UdeAMedellínColombia
  2. 2.Grupo de Neurociencias de Antioquia, Facultad de MedicinaUniversidad de Antioquia UdeAMedellínColombia
  3. 3.Grupo Neuropsicología y Conducta, Facultad de MedicinaUniversidad de Antioquia UdeAMedellínColombia

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