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White matter integrity disparities between normal-weight and overweight/obese adolescents: an automated fiber quantification tractography study

  • Kaylie A. Carbine
  • Kara M. Duraccio
  • Ariana Hedges-Muncy
  • Kimberly A. Barnett
  • C. Brock Kirwan
  • Chad D. JensenEmail author
ORIGINAL RESEARCH
  • 25 Downloads

Abstract

Obese adults have been shown to have poorer white brain matter integrity relative to normal-weight peers, but few studies have tested whether white matter integrity is compromised in overweight and obese adolescents. Also, it is unclear if age interacts with body mass to affect white matter integrity in adolescents. We used Automated Fiber Quantification, a tractography method, to compare fractional anisotropy between normal-weight and overweight/obese adolescents in the corpus callosum, corticospinal tract, cingulum, inferior fronto-occipital fasciculus, and uncinate fasciculus. Further, we tested whether any differences were moderated by age. Forty-seven normal-weight and forty overweight/obese adolescents were scanned using a diffusion tensor imaging (DTI) scan sequence. Overweight/obese compared to normal-weight adolescents had decreased white matter integrity in the superior frontal corpus callosum, left and right uncinate fasciculi, left inferior fronto-occipital fasciculus, and left corticospinal tract, which may be related to heightened reward processing. Overweight/obese compared to normal-weight adolescents had increased white matter integrity in the orbital and anterior frontal corpus callosum, right inferior fronto-occipital fasciculus, left cingulum, and left corticospinal tract, which may be related to heightened attentional processing. As age increased, six tracts showed poorer white matter integrity as body mass index percentile (BMI%) increased, but three tracts showed greater white matter integrity as BMI% increased. Future research examining associations between white matter integrity and neural indices of food-related reward and attention are needed to clarify the functional significance of white matter integrity discrepancies between normal-weight and overweight/obese adolescents.

Keywords

Diffusion tensor imaging (DTI) Automated fiber quantification (AFQ) Fractional anisotropy (FA) White matter integrity Adolescents Overweight/obesity 

Notes

Acknowledgements

We thank Naomi Goodrich-Hunsaker, Ph.D., for assistance with data analysis.

Funding

This study was funded by a Brigham Young University Mentoring Environment Grant.

Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest to report.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Kaylie A. Carbine
    • 1
  • Kara M. Duraccio
    • 1
  • Ariana Hedges-Muncy
    • 1
  • Kimberly A. Barnett
    • 1
  • C. Brock Kirwan
    • 1
    • 2
  • Chad D. Jensen
    • 1
    Email author
  1. 1.Department of PsychologyBrigham Young UniversityProvoUSA
  2. 2.Department of NeuroscienceBrigham Young UniversityProvoUSA

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