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Long-term brain effects of N-back training: an fMRI study

  • Anna Miró-Padilla
  • Elisenda Bueichekú
  • Noelia Ventura-Campos
  • María-Jesús Flores-Compañ
  • Maria Antònia Parcet
  • César Ávila
Original Research

Abstract

Neurobehavioral effects of cognitive training have become a popular research issue. Specifically, behavioral studies have demonstrated the long-term efficacy of cognitive training of working memory functions, but the neural basis for this training have been studied only at short-term. Using fMRI, we investigate the cerebral changes produced by brief single n-back training immediately and 5 weeks after finishing the training. We used the data from a sample of 52 participants who were assigned to either an experimental condition (training group) or a no-contact control condition. Both groups completed three fMRI sessions with the same n-back task. Behavioral and brain effects were studied, comparing the conditions and sessions in both groups. Our results showed that n-back training improved performance in terms of accuracy and response speed in the trained group compared to the control group. These behavioral changes in trained participants were associated with decreased activation in various brain areas related to working memory, specifically the frontal superior/middle cortex, inferior parietal cortex, anterior cingulate cortex, and middle temporal cortex. Five weeks after training, the behavioral and brain changes remained stable. We conclude that cognitive training was associated with an improvement in behavioral performance and decreased brain activation, suggesting better neural efficiency that persists over time.

Keywords

fMRI n-back Cognitive training, long-term effects Working memory 

Notes

Acknowledgments

This research was supported by grants from Jaume I University (P1•1B2013-63) and Ministerio de Economia y Competitividad (PSI2013-47504-R and PSI2016-78805-R). Authors AMP, EB and MJFC were supported by pre-doctoral graduate program grants (Jaume I University FPI to AMP; National FPU to EB; and National FPI to MJFC).

Funding

This research was supported by grants from Jaume I University (P1•1B2013–63) and Ministerio de Economia y Competitividad (PSI2013–47504-R and PSI2016–78805-R). Authors AMP, EB and MJFC were supported by pre-doctoral graduate program grants (Jaume I University FPI to AMP; National FPU to EB; and National FPI to MJFC.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance wit the ethical standards of the institutional Review Board of the Universitat Jaume I and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

11682_2018_9925_MOESM1_ESM.docx (491 kb)
ESM 1 (DOCX 491 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Neuropsychology and Functional Neuroimaging Group, Department of Basic Psychology, Clinical Psychology and PsychobiologyUniversitat Jaume ICastellónSpain
  2. 2.Department of EducationUniversitat Jaume ICastellónSpain

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