Medicine Meets Thermal Spray Technology: A Review of Patents

  • J. Cizek
  • J. Matejicek


The patent literature concerning thermal spraying for biomedical applications is reviewed in this contribution. The patents were compiled from multiple databases search spanning the 2005-2018 period. For clarity and ease of reading, the results have been grouped into sections according to four individual material groups (apatites, titanium, oxide ceramics, other), with the secondary sorting criterion being related to the specific bioapplication areas (maxillofacial, orthopedic, methods). Lastly, the patents are grouped according to the selected thermal spray method within the individual subsections. In the paper, recent R&D trends in this field are further identified and briefly commented.


applications atmospheric plasma spray (APS) biomaterials cold spray feedstock HVOF hydroxyapatite processing titanium wire arc spray 



Compilation of the paper was supported through Czech Science Foundation grant GB14-36566G “Multidisciplinary research centre for advanced materials.”


  1. 1.
    K.A. Gross and E. Ezerietis, Juniper Wood as a Possible Implant Material, J. Biomed. Mater. Res., 2003, 64A, p 672-683CrossRefGoogle Scholar
  2. 2.
    M.E. Pons, Developing Hydroxyapatite CAPS Coatings on Metallic Implants for Tissue Replacement, Ph.D. Thesis, Nanyang Technological University, Singapore 2004Google Scholar
  3. 3.
    R.E. Ant and I. Wang, Physical and Chemical Aspects of Biomaterials Used in Humans, in Implantation Biology: The Host Response and Biomedical Devices. CRC Press, Boca Raton, 1994, p. 13-38Google Scholar
  4. 4.
    R.C. Eberhart, H. Huo, and K. Nelson, Cardiovascular Materials, MRS Bull., 1991, 16, p 50-54CrossRefGoogle Scholar
  5. 5.
    P. Chagnon and P. Fauchais, Thermal Spraying of Ceramics, Ceram. Int., 1984, 10(4), p 119-131CrossRefGoogle Scholar
  6. 6.
    S. Sampath, X.Y. Jiang, J. Matejicek, L. Prchlik, A. Kulkarni, and A. Vaidya, Role of Thermal Spray Processing Method on the Microstructure, Residual Stress and Properties of Coatings: An Integrated Study for Ni-5 wt.%Al Bond Coats, Mater. Sci. Eng. Struct. Mater. Prop. Microstruct. Process., 2004, 364(1–2), p 216-231CrossRefGoogle Scholar
  7. 7.
    J. Cizek, K.A. Khor, and I. Dlouhy, In-Flight Temperature and Velocity of Powder Particles of Plasma-Sprayed TiO2, J. Therm. Spray Technol., 2013, 22(8), p 1320-1327CrossRefGoogle Scholar
  8. 8.
    V. Palka, E. Postrkova, and H.K. Koerten, Some Characteristics of Hydroxylapatite Powder Particles after Plasma Spraying, Biomaterials, 1998, 19(19), p 1763-1772CrossRefGoogle Scholar
  9. 9.
    Clarivate Analytics, Web of Knowledge—Derwent Innovation Index.
  10. 10.
    European Patent Office, Espacenet.
  11. 11.
    United States Patent and Trademark Office, Patent Full-Text Databases.
  12. 12.
    Q. Bao and T. Brown, Implantable device i.e. Weight-Bearing Implant, for Being Implanted into Weight-Bearing Joint, has Camming Surface Connected to Implant Body, Where Mechanical Bond Strength Between Implant Body and Coating About Specific MEGA PASCAL, US2009276053-A1, 2009Google Scholar
  13. 13.
    T.C. Prentice and A.R. McCabe, Applying a Coating to a Substrate Material, Comprises Plasma Spraying Powder of Titanium Dioxide onto a Substrate Material to Form an Initial Coating, and Applying A Further Coating of Metal and/or Hydroxyapatite onto the Initial Coating, WO2012110816-A1, 2012Google Scholar
  14. 14.
    R. Ahmed and G.H. Markx, Coating an Article, e.g. Implant for Surgical or Dental Use Involves Spray Coating the Powder Comprising Coated Particles onto Surface of Article to Form Composite Coating, US9421151-B2, 2016Google Scholar
  15. 15.
    O.A. Dudareva, I.P. Grishina, V.N. Lyasnikov, and A.V. Lyasnikova, Method for Making Implants Involves Multilayer Plasma Spraying of Biologically Active Coating onto Metallic Substrate of Implants, RU2529262-C1, 2014Google Scholar
  16. 16.
    L. Jiang, S. Lin, and L. Wang, Titanium-Hydroxylapatite Gradient Coating for Titanium Alloy Implant Surface, has Titanium Powder Layer, Two Titanium Powder and Hydroxylapatite Mixed Layers and Hydroxylapatite Layer that are Arranged from Inside to Outside, CN101612418-A, 2009Google Scholar
  17. 17.
    L. Gan, S.C. Jani, M.L Scott, Marcus, and S.C. Giani, Coating for Medical Implant, Comprises Osseointegration Agent and Antimicrobial Metal Agent Comprising Silver, Copper and/or Zinc, US9839720-B2, 2017Google Scholar
  18. 18.
    Y. Chen, X. Zheng, H. Ji, C. Ding, and Y. Xiang, Antimicrobial Type Hydroxyapatite Composite Coating Includes Metal Silver Powder as Antimicrobial Additive Ingredient and Hydroxyapatite Powder, CN100549109-C, 2009Google Scholar
  19. 19.
    J. Zhou, Iodine Antibacterial Hydroxyapatite Composite Coating Used for Coating Titanium and Titanium Alloy Based Substrate Used as Prosthetic Implant, Comprises Hydroxyapatite and Povidone Iodine Particles, CN102417741-A, 2012Google Scholar
  20. 20.
    L. Song, Y. Huang, L. Gan, Y. Wu, X. Liu, F. Wu, Y. Xiao, and Z. Tian, BIOMEDICAL MATERIAL i.e. Hydroxyapatite Coating Containing Silver ion Biomaterial, Contains Hydroxyapatite Coating that Contains Silver ion Which is Sprayed on Substrate Material by Plasma, CN101797399-A, 2010Google Scholar
  21. 21.
    H. Gruner, P. Gruner, and F. Tourenne, Implant i.e. Cement-Less Implanted Prosthesis, for e.g. Traumatology, has Cover Layer Formed of Powder by Application of Thermal Spray Method, Where Powder has Calcium Phosphate e.g. Hydroxylapatite, and Antibacterial Active Ingredients, EP2224970-B1, 2018Google Scholar
  22. 22.
    J. Fencl, J. Fojt, and L. Joska, Revision joint Implant Device for Performing Total Replacement of Femoral and Acetabular Components, has Transition Portion Whose Outer Surface is Provided with Protective Porous Surface Layer that is Matched with Integral Surface Layer, CZ306816-B6, 2017Google Scholar
  23. 23.
    J. Chen, J. Feng, Y. Huang, X. Liu, L. Song, F. Wu, Y. Xiao, and J. Cheng, Preparation of Multiple Pore Hydroxyapatite Coating on Biomedical Material, e.g. Titanium, by Spraying Plasma of Hydroxyapatite Suspending Liquid, Adding Pore-Creating Agent, e.g. Ethanol, Injecting to Plasma Flame Kernel, and Sedimenting, US8877283-B2, 2014Google Scholar
  24. 24.
    F. Wu, L. Song, Y. Xiao, X. Liu, Y. Huang, Y. Wu, and J. Chen, Suspension Injection Type Plasma Spray Coating Device For Preparing Biologically Active Hydroxyapatite Coating, Comprises Plasma Spray Gun, Metal Substrate, Substrate Fixed Beam, Storage Container, Suspension Conveying and Injection Systems, CN101250682-B, 2011Google Scholar
  25. 25.
    J. Chen, Y. Huang, X. Liu, L. Song, F. Wu, Y. Wu, and Y. Xiao, Suspending Liquid Injection Plasma Spraying Device Useful for Preparing Biological Active Coating Of Hydroxyapatite, Comprises a Plasma Spray Gun, a Metal Substrate, a Substrate Fixing Rack, and a Suspending Liquid Conveying System, CN201195743-Y, 2008Google Scholar
  26. 26.
    F. Wu, Y. Huang, X. Liu, Y. Wu, Y. Xiao, L. Song, and J. Chen, Preparation of Hydroxyapatite Biological Activity Coat by Spray Coating Suspension Plasma for Medical Consumption Comprises Preparing Hydroxyapatite Suspension, Transferring, Pouring and Generating Hydroxyapatite Biological Activity Coat, CN101250681-B, 2010Google Scholar
  27. 27.
    R.E. Riman and C. Sever, Preparation of Nanoscale Hydroxyapatite Particles Useful e.g. as Granular Fill Compounds, Bone Implant Materials Involves Combining Calcium Ion Source Having Calcium Acetate and Phosphate Ion Source Under Ambient Conditions, US8287914-B2, 2012Google Scholar
  28. 28.
    T. Huang, J. He, L. Gan, Y. Wu, F. Wu, and Z. Tian, Biomedical Material for Bone Formation, has Substrate Material Whose Surface is Compounded with Porous Calcium Phosphate Coating that is Compounded with Collagen so as to Build Porous Calcium Phosphate-Collagen Composite Coating, CN102145194-A, 2011Google Scholar
  29. 29.
    J. Fencl and J. Simek, Surface Treatment of Implants, that is Bone Preferably Joint Implants, Comprises Thermal Application of a Mixture of a Powdered Material Containing Hydroxyapatite Powder, and Titanium Powder on Surface, CZ201500934-A3; CZ306822-B6, 2017Google Scholar
  30. 30.
    S. Ban, L. Cui, D. He, J. Jiang, X. Li, Z. Wang, L. Zhao, Q. Zhao, and Z. Zhou, Preparation method for Making Hydroxyl Apatite Coating Through Cold Spraying, Involves Spraying Dried Hydroxyl Apatite Powders onto Matrix of Biomedical Implanted Metal Material Using Cold Spraying Device, CN101591777-B, 2011Google Scholar
  31. 31.
    S. Ban, L. Cui, D. He, J. Jiang, X. Li, Z. Wang, L. Zhao, Q. Zhao, and Z. Zhou, Preparation Method of Hydroxyl Apatite Coating by Micro-beam Plasma Spraying for Medical Implant Pieces of Tooth Root and Artificial Joint Involves Providing Powder Conveying Gas with Predetermined Flow Rate and Conveying Rate, CN101591759-B, 2011Google Scholar
  32. 32.
    B. Hou, Y. Huang, T. Li, Z. Liu, Z. Qiao, Z. Xiong, G. An, and G. Qin, Crystallization of Plasma-Sprayed Hydroxyapatite Coating Used for Surgical Implant, Involves Providing Hydroxyapatite Coating Product into Closed Container, Introducing Vacuum and Saturated Steam, Heating Container, and Cooling, CN104164644-A, 2014Google Scholar
  33. 33.
    B. Yang, Y. Huang, J. Feng, J. Chen, and X. Zhang, Method for Post Treatment of Plasma Spraying Hydroxyapatite Coating, CN100357485-C, 2007Google Scholar
  34. 34.
    Y. Lu, J. Wang, and M. Li, Surface Nanocrystallization Method For Hydroxyapatite Coating, CN100348276-C, 2007Google Scholar
  35. 35.
    H. Grundei, Subcutaneous Intramuscular Camp for Rigid Transcutaneous Implant in Bone Stump, Comprises Distance Piece Having Rigid Socket Surface with Intracorporal Coupling Element and is Placed Between Implant and Extracorporal Coupling Device, EP1827317-B1, 2006Google Scholar
  36. 36.
    H. Zimmermann, Thermal Sprayed Surface Layer Made of Titanium on a non-metallic Substrate of an Orthopedic Implant, Comprises an x-Ray-Sensitive Mixture Made of Biocompatible Indicator Metal in Relation to Titanium, EP2199423-B1, 2013Google Scholar
  37. 37.
    R. Lerf, H. Schmotzer, and S. Siegmann, Open-Pore Biocompatible Surface Layer for Application to an Implant Comprises a Coherent Pore Network and has a Defined Surface Area, EP1942961-B1, 2013Google Scholar
  38. 38.
    Y. Xie and J. Zeng, Manufacture of Patterned Titanium-Coated Hard Tissue Replacement Material Involves Sand-Blasting Metal Implant, Cleaning, Spraying Titanium Powder on Metal Implant by Arc Plasma Method, and Forming Titanium Surface Layer, CN103805987-B, 2016Google Scholar
  39. 39.
    S. Cheng and X. Lu, Human Body Bone Substitute Connecting Piece for Use as Biological Medical Material, has Human Body Bone Substitute Connecting Piece Base Provided with Porous Titanium Surface Layer that is Coated with Titanite Layer, CN202982311-U, 2012Google Scholar
  40. 40.
    V.M. Frauchiger, S. Jaggi, and T. Wippich, Plasma Spray Process for Modifying Substrate Used in e.g. Hip Implants Involves Introducing two Materials into Plasma Source to Produce a Plasma Spray, Where Second Material at Least Partially Melts in the Plasma and Binds to First Material, WO2010037562-A2, 2010Google Scholar
  41. 41.
    M. Mitrovic, Method for Producing Structured Coating on Part of Surface of Artificial Femoral Knee Joint Implant to be Placed in Femur for Joint Replacement, Involves Hardening thin Layer, and Abrasively Processing and Functionalizing Produced Layer, WO2012126448-A1, 2012Google Scholar
  42. 42.
    J. Schleicher, J.K. Barrett, and J. Ault, Coating Cobalt-Chromium Alloy Medical Implant, by Applying Coating of Pure Titanium to Surface of Medical Implant by Cold Spray Process, and Diffusion Bonding Coating and CoCr Alloy Medical Implant Using Hot Isostatic Pressing, WO2014137316-A1; CA2903188-A1; EP2964802-A1; US2016030632-A1; EP2964802-A4, 2014Google Scholar
  43. 43.
    M. Kumar, Making Implant for Replacing Joint of Patients Involves Coating Textured Dies Surface with Powdered Metal, Injecting Slurry into Die Cavity, Casting Slurry Material, Removing Ceramic Shell, Plasma Spraying Layer onto Surface of Stable Dome, US2010136214-A1, 2010Google Scholar
  44. 44.
    M. Kumar, Formation of Acetabular Cup by Providing Working Surface, Spraying First Layer of Material Having First Composition onto Working Surface Defining Acetabular Shell, and Removing Acetabular Shell from Working Surface, US7655162-B2, 2010Google Scholar
  45. 45.
    X. Liu, X. Zhao, and C. Ding, Preparing Nano-Titanium Oxide Coating Layer Having Bioactivity, CN100346001-C, 2007Google Scholar
  46. 46.
    R.S. Lima, B.R. Marple, H. Li, and K.A. Khor, Making of Biocompatible Coating for an Implant, e.g. Component of Artificial Hip Joint, Involves Thermally Spraying the Particles onto Substrate to Form Coating, and Controlling the Spray Parameters, US2006199024-A1, 2006Google Scholar
  47. 47.
    H. Zheng and X. Zaho, Preparing Titanium-Niobium Oxide Composite Coating for Surface Activation Treatment Comprises Preparing Coating Powders, Material Cleaning and Sand Blasting, Plasma Spraying, and Soaking in Energy Body Fluid, CN102816988-B, 2014Google Scholar
  48. 48.
    L. Huang, H. Ji, Y. Liang, Y. Xie, and X. Zheng, Bone Replacing Material of Baghdadite Coating-Titanium Alloy, Useful for Inducing Formation of Bone-Like Apatite in Simulated Body Fluid, Comprises Titanium and Its Alloy as Matrix and Coating is Deposited on Matrix by Plasma Spray Coating, CN102049065-A, 2011Google Scholar
  49. 49.
    J. Chang, C. Ding, Y. Xie, W. Zhai, and X. Zheng, Hard Tissue Substitute Comprises Magnesium Silicate Coating Layer Which is Coated on Substrate such as Titanium or Titanium Alloy, CN101658693-B, 2008Google Scholar
  50. 50.
    D.E. Lawrynowicz, H. Zeng, and Z. Zhang, Producing Refined Chromium Oxide Powder, Useful in Thermal Spraying a Coating on an Implant (which is medical implant), Comprises Acid and Reduction Washing of Chromium Oxide Powder, and PACKAGING the Chromium Oxide Powder, US2009162273-A1, 2009Google Scholar
  51. 51.
    W.J. Dalzell and K.H. Heffner, Integration of Radiation Shield, e.g. Tungsten, with Implantable Medical Device with Biocompatible Coating, e.g. Pacemaker, Involves Thermally Spraying Radio-Opaque Composition Particularly Around Electronic Circuitry of Medical Device, US2007055147-A1, 2007Google Scholar
  52. 52.
    E. Garofalo, M. Meehan, R. Montalbano, J. Wang, J. Whalen, and E. Garafalo, Forming Porous Metal Coating Over Substrate, by Thermally Spraying Metal Coating Material Over Surface of Substrate to form Applied coating Including Impurity-Rich Portion, and Removing The Portion of Applied Coating to Form the Coating, US9023419-B2, 2015Google Scholar
  53. 53.
    D.E. Lawrynowicz, A. Wang, Z. Zhang, and J. Krajewski, System for Applying Coating of Desired Material onto Medical Implant Component, Comprises Thermal Sprayers, Rotatable Holding Fixture Having Mounting Stations, Feeders for Supplying the Desired Material to the Sprayers, and Control Device, US7981479-B2, 2011Google Scholar
  54. 54.
    S. Koenig and H. Schmotzer, Open-pore Biocompatible Surface Layer for Use as Implant for Hip Shaft, Bowls for Hip Joints, Femur Components for Knee Joint Replacement, Shinbone Components for Knee Joint Replacement, is Disposed on Raw Surface of Implant, WO2009097968-A3, 2009Google Scholar
  55. 55.
    R.E. Brosnahan, R. Fesmire, H. Gupta, D.A. Heuer, G. Hunter, and V. Pawar, Manufacturing Medical Implant e.g. Hip Implant Having Oxidized Zirconium Surface and Porous Coating, by Forming Implant, Oxidizing Implant to Form Surface of Oxidized Zirconium, and Applying Coating to Portion of Implant by Plasma Spray, US2009012611-A1, 2009Google Scholar
  56. 56.
    D.E. Lawrynowicz and A. Wang, Fabricating Medical Implant Component such as Femoral Ball Head Component, Useful in e.g. Hip Replacement Surgery Involves Spraying Particles on Bearing Portion of Substrate; and Subjecting Coated Bearing Portion to Vacuum Sintering Process, EP1806155-B1, 2010Google Scholar
  57. 57.
    A. Wang, D.E. Lawrynowicz, Z. Zhang, and D. Lawrynowicz, Medical Implant Component e.g. Femoral Ball Head Component, Fabrication for e.g. Hip Replacement Surgery, Involves Spraying Particles of Ceramic Material onto Bearing Portion of Substrate by Thermal Type Spraying Process, EP1808186-B1, 2010Google Scholar
  58. 58.
    P.A. Kramer, Manufacturing Medical Device e.g. Drug Eluting Stent, Guide Wires, Lead Tips, Catheters, Markers Involves Forming Porous Substrate from Biocompatible Material Using Spray Process and Processing Porous Substrate INTO Medical Device, US7514122-B2, 2009Google Scholar
  59. 59.
    M.N. Bureau, J. Legoux, S. Belanger, and J.G. Legoux, Tie layer for Bonding Ceramic or Metallic Coating to Thermoplastic Substrate such as Implantable Prosthetic Bone, Contains Filler Particles such as Ceramic and/or Metallic Particles in Thermoplastic Matrix that is Compatible with Substrate, CA2593781-C, 2011Google Scholar
  60. 60.
    C.P. Cornelius, R. Schoutens, R. Gheorghe, and A. Mootien, Mandibular Bone Plate for Use With Mandible, has Extension Portion for Defining Bone Facing Surface, Where Extension Portion is Oriented such that line Tangential to Inferior End and Superior End of Bone Facing Surface is Rotated, WO2014158740-A1, 2014Google Scholar
  61. 61.
    V.N. Lyasnikov, O.D. Muktarov, and V.V. Perinskii, Method for Making Intraosseous Carbon-Nanocoated Dental Implant Involves Sand-Blast Finish of an Implant Surface by Aluminium Oxide Particles, RU2490032-C1, 2013Google Scholar
  62. 62.
    N. Urakabe and S. Urakabe, Dental Implant Useful in Surgery Process, has Cylindrical Core Material and Recrystallized Apatite-Based Ceramic Coating Layer Having Two or More Calcium-Phosphate-Type Compounds Which Differs in Melting Points, JP5891150-B2, 2016Google Scholar
  63. 63.
    F. Nakada, Component for Installing Artificial Hip Joints in Recess Cover of Pelvis, has Liner Whose Outer Surface is Provided with Opposing Surface Facing Another Surface, Where Opposing Surfaces are Made to Contact with Sides of Recessed Part, JP2013063103-A, 2013Google Scholar
  64. 64.
    B.W. Schneider, R. Simon, D. Lindsey, and S.A. Yerby, Modular Implant for Fixation/Fusion of Sacroiliac Joint, has Transverse Support Struts Arranged in Rectilinear Configuration at Proximal and Distal Ends of Repeating Internal Portion which is Positioned Between Distal and Proximal Portions, US2017296244-A1, 2017Google Scholar
  65. 65.
    B.W. Schneider, R. Simon, D. Lindsey, and S.A. Yerby, Modular Straight Implant for Performing Fixation or Fusion of Sacroiliac Joint of Patient for e.g. Degenerative Sacroiliitis, has First Guide Pin Receptacle Located Along Longitudinal Axis of Solid Elongate Body, US9662157-B2, 2017Google Scholar
  66. 66.
    B. Walter, D. Brazil, and T. McTighe, Femoral Prosthesis e.g. Hip Prosthesis, for Installing or Fixing at Proximal End of Proximal Femur of Human Patient in Total Hip Replacement Procedure, has Thinner Connecting Body Placed Between Columns, Where Columns are Spaced Apart, US8470049-B2, 2013Google Scholar
  67. 67.
    N. Hansell, E. Dwyer, and J. Bennett, Artificial Disc, Useful for Replacing Damaged Intervertebral Disc, Comprises Superior Core with Superior Surface Provided to Contact Inferior Surface of Superior Endplate, Inferior core to Connect to Superior Core, and Inferior Endplate, US9017410-B2, 2015Google Scholar
  68. 68.
    A. Balasubramanian, J. Bennett, N. Hansell, and J.B. Bennett, Artificial Disk for e.g. Replacing Intervertebral Disks, of Patient Injured or Damaged as Degenerative Disk Disorder Result, has Support Assembly Placed on Outer Surfaces of Endplates and for Coupling Superior Endplate to Inferior Endplate, US9937051-B2, 2018Google Scholar
  69. 69.
    S.D. Cook and S.L. Salkeld, Implant Device for Treating Lumbar Spinal Stenosis of Patient, has Vertebral Attachments Comprising Connecting Components that Affix Magnets to Superior or Inferior Vertebrae, Where Connecting Components Comprise Extension, US2014025122-A1, 2014Google Scholar
  70. 70.
    S. Petersheim and R. Agard, Bone Plate i.e. Spinal Plate, for Joining Adjacent Vertebrae to Treat Spinal Deformities, has Ridge Connected to Bottom Part and Inserted into Bone, and Hole Receiving Bone Screw for Attaching Plate to Bone, EP2753256-A1, 2014Google Scholar
  71. 71.
    P. Raugel and E. Jones, Flexible Acetabular Cup makes External Choral Dimensions of Cup, Which Runs Across Separation or Opening Between Arms, Greater than External Diameter of Partly Spherical Portion, EP1884220-B1, 2011Google Scholar
  72. 72.
    Y. Hai, Q. Luan, and Z. Zhou, Cost-Effective Artificial Bone with High Strength, Excellent Hardness, Toughness, and Corrosion Resistance, Comprises Middle Layer Comprising high Strength Carbon Fiber, CN202355616-U, 2012Google Scholar
  73. 73.
    T.C. Prentice, R.L. David, M.E.L. Pickford, and A.D. Turner, Implant Useful in Surgical Procedure e.g. Hip Replacement, Contains Metal Structure Coated with Biocompatible Metal by Plasma Spraying, and Biocidal Metal Cations Incorporated in Coating, EP2101835-B1, 2010Google Scholar
  74. 74.
    T.C Prentice, M.E.L. Pickford, D.R Lewis, and A.D. Turner, Implant for Contacting with a Bone During e.g. Prosthetic Surgery, Comprises Metal Structure Having a Surface with a Ceramic Coating Containing Hydroxyapatite and Silver Ions that Gradually Leach out in Body Fluids After Implantation, EP2316499-B1, 2013Google Scholar
  75. 75.
    H. Ao, Y. Liu, Y. Chen, H. Chen, C. Wang, W. Yuan, X. Wu, X. Wang, and X. Zheng, Plasma Spray Coating Orthopedics Screw, has Screw Main Body Whose Surface is Coated with Plasma Spray Coating, Where Screw Main Body is Made of Titanium Alloy, CN202288439-U, 2012Google Scholar
  76. 76.
    B.D. Hahn and D.S. Park, Preparation of Nano-structured Hydroxyapatite Coating Layer, Comprises Putting Hydroxyapatite Powder in Powder Chamber, Placing Metal Substrate in Deposition Chamber, and Keeping Deposition Chamber in Vacuum State Using Vacuum Pump, US2011281127-A1, 2011Google Scholar
  77. 77.
    C.G. Sidebotham, Load Bearing Implant, Useful for Medical Applications Including e.g. Femoral Head Replacement for Hip, Comprises Femoral Implant Stem Having Male Locking Tapered Fitting for Attachment to Internal Female Taper of Head, and Neck-Collar Area, US8778030-B2, 2014Google Scholar
  78. 78.
    A. Podolsky and Y. Garbuzov, Dual-Taper Lock Modular Prosthetic Hip System for Performing Minimally Invasive Total- or Hemi Hip Arthroplasty in Hip of Patient, has Prosthetic Femoral Head Implant Rotatably Fitted Within Acetabulum, US8579985-B2, 2013Google Scholar
  79. 79.
    S. Abdou, Orthopedic Device Assembly for Concurrently Placing Implantable Spacers into Intervertebral Disc Space Between Superior and Inferior Vertebral Bones, has non-Implantable Placement Instrument with Cavity Containing Bone Forming Material, US8845728-B1, 2014Google Scholar
  80. 80.
    P. Brun, S. Chegini, and P. Lindenmann, Intervertebral Implant i.e. Orthopedic Implant, for Implant Assembly to Implant in Intervertebral Disk Space in e.g. Spine Region, has Fixation Assembly Rotated Within Implant Body About Transverse Axis from Retracted to Extended Position, US8545563-B2, 2013Google Scholar
  81. 81.
    D.C. Blackburn, V. Carvajal, R.H. Dixon, C.F. Gardinier, D.P. Harding, T. Medford, B.J. Pope, J.K. Taylor, Component for Prosthetic joint e.g. Artificial Hip Joint, Comprises Sintered Carbide Substrate Comprising Titanium Carbide and Titanium Sintering Metal, Sintered Diamond Articulation Surface Formed on Substrate, and Bone Attachment Surface, US8603181-B2, 2013Google Scholar
  82. 82.
    T. Vanasse, G. Gupta, and J. Meridew, Medical Implant for e.g. Replacing Joint of Shoulder of Human Body During Shoulder Procedure, has Metallic Body Whose Surface is Replicated from High Resolution Scan of Bone and Promoting Bony On-Growth or In-Growth of Tissue, US2014371863-A1, 2014Google Scholar
  83. 83.
    M. Dai, Implantation Material for Surgery in Use for Repairing Bone, CN100364618-C, 2008Google Scholar
  84. 84.
    J. Tyber and C. Faresich, Osteotomy Implant of Osteotomy Implant System Used for Internal Fixation of Bone Fracture, in which Surfaces Extend in Respective Planes, US2018008419-A1, 2018Google Scholar
  85. 85.
    J. Sun, Y. Han, and K. Cui, Compound Technique for Preparing Multiaperture Titanium Coating by Cold Spray and Vacuum Sintering, CN100560143-C, 2009Google Scholar
  86. 86.
    A.Z. Rosenflanz, R.P. Rusin, and J.E. Swanson, Manufacture of Dental Article or Orthodontic Appliance, e.g. Brackets, by Plasma or Thermally Spraying Particles Comprising Metal Oxide Sources on a Substrate Such that the Particles Coalesce to Form Shaped Article Comprising Aluminum Oxide, US2005136176-A1, 2005Google Scholar
  87. 87.
    C. Li, Z. Wang, L. Zhu, N. Gao, D. Hao, H. Wang, J. La, M. Guo, and H. Li, Plasma-Spray-Coated Nano Zirconia Implant has Implant Component Containing Titanium or Titanium Alloy Material Having Monolithic Structure, and Base Having Transgingival Shoulder Portion Having Uniform Coating of Nano-Zirconia, CN104042350-A, 2014Google Scholar
  88. 88.
    G.A. Walther, Implant e.g. Tooth Implant, for Implanting in Bone i.e. Jawbone, has Implant Body Inserted into Human Jawbone, and Implant Support Inserted into Body, where Area Engaged into Jawbone is Provided with Coating Made from Ceramic Material, EP2361586-A1, 2011Google Scholar
  89. 89.
    P. Jensen, Dental Device e.g. Orthodontic Archwire, has Metallic Substrate Made Of Titanium, Titanium Oxide, Nickel Titanium, Vitalium or Chrome Cobalt, Where Device is Coated with Combination of Aluminum Oxide and Zirconia, US2011183281-A1, 2011Google Scholar
  90. 90.
    T. Hotokebuchi and I. Noda, Antimicrobial Product Useful in Biological Implant e.g. Artificial Dental Root, Comprises Thermal Spraying Film Formed by High-Speed Flame Spraying Powder Having Brookite-Type Titanium Oxide on Metal, Ceramic or Plastic Substrate, JP5308754-B2, 2013Google Scholar
  91. 91.
    A. Djemai, J.J. Fouchet and J. Fouchet, Formation of Beta Phase-Titanium-Zirconium Alloy for Manufacturing e.g. Dental Implant, Involves Stacking Layers Of Metal Powders, and Selectively Fusing Powders by Concentrating Laser-Beam or Using Sintering Modular Energy Source on Layers, FR3047489-A1; WO2017137671-A1, 2017Google Scholar
  92. 92.
    J. Cheng, Highly Connected Dental Structure for Dental Prostheses, has Ceramic Layer Which is Applied on the Inner and Outer Surfaces of Metal Cap Using a Plasma Spray Process, DE102011051594-A1, 2013Google Scholar
  93. 93.
    D. Wu, C. Zhining, C. Wan, and Q. Wang, IMPLANT For Bone Repair and Tooth Implant Comprises Strontium-Doped Calcium Polyphosphate Layer Coated on Surface of Matrix and Titanium Matrix, CN101927034-A, 2010Google Scholar
  94. 94.
    J.A. Sharp, Orthopedic Implant for Replacing Hip Joint with Prosthetic Joint During Replacement/Revision Hip Surgery of Patient, has Expansion Member Placed Between Portions and Adjusted by Tightening Tool to Displace Portions Relative to Each Other, WO2011156511-A3, 2011Google Scholar
  95. 95.
    R.G. Mauldin and R. Mauldin, Tubular Threaded Bone Implant for Fixation of Sacroiliac Joint e.g. for Degenerative Sacroiliitis, Has Set of Pores Defined on Body Such That Each Pore Does not Extend Through Entire Thickness of Wall of Body Between Surfaces of Body, WO2013134678-A1, 2013Google Scholar
  96. 96.
    M.A. Reiley, J. Lerman, and R.G. Mauldin, Method for Fusion of Sacral-Iliac Joint Between Iliac and Sacrum, Involves Inserting Bone Fixation Implant into Lateral Insertion Path Created Laterally Through Ilium, Sacral-Iliac Joint and Sacrum, US8986348-B2, 2015Google Scholar
  97. 97.
    T.D. Ferro, J.R. Phillips, and A.T. Ferro, Implant Device e.g. Cementless Unicompartmental Knee Replacement Implant Device, has Tapered Protrusions Extending from Surface of Base That Mates with Bone, Where Surface of Each Protrusion Includes Surface to Increase Area for Bone Growth, US2017312084-A1, 2017Google Scholar
  98. 98.
    J.P. Ritz and C. Scott, Making Bone Implant Used for Repair of the Ends of Bones at Orthopedic Joints Involves Creating Substrate of Structurally Strong Isotropic Graphite of the Shape Desired for Bone Implant, and coating with Microporous Isotropic Pyrocarbon, US8932663-B2, 2015Google Scholar
  99. 99.
    J.R. Porter, N.A. Winslow, J. Kneisl, and J.W. Sperling, Orthopedic Implant for use in Orthopedic Surgery e.g. Shoulder Arthroplasty, has Locking Mechanism that Prevents Movement of Soft Tissue Attachment Pad with Respect to Implant, US8715356-B2, 2014Google Scholar
  100. 100.
    H. Wecker and A. Rempp, Ceramic Layer Applied to the Surface of Component by Means of a Thermal Spraying Process, Useful for Functionalization of Medical Devices, Preferably Prostheses and Implants, WO2017055270-A1, 2017Google Scholar
  101. 101.
    R.E. Brosnahan, R. Fesmire, H. Gupta, D.A. Heuer, G. Hunter, and V. Pawar, Medical Implant for e.g. hip Joint, Has Surface of Oxidized Zirconium Adapted on Portion of Femoral and Tibial Components, and Plasma Sprayed Porous Coating Applied on Portion of Surface of Oxidized Zirconium, US2006052880-A1, 2006Google Scholar
  102. 102.
    D.E. Lawrynowicz, A. Wang, and Z. Zhang, Fabrication of Medical Implant Component Involves Producing Substrate Having Bearing Surface that Articulates with Bone or Another Medical Implant, and Spraying Particles of Same or Different Material Using Thermal Type Spraying Process, US7771775-B2, 2010Google Scholar
  103. 103.
    D.E. Lawrynowicz, A. Wang, and E. Jones, Providing Reactive Material on a Portion of Surface of Substrate of Medical Implant Component e.g. Femoral Stem Involves Placing Component in Holding Fixture at Atmospheric Pressure; and Spraying Material Particles at Predetermined Velocity, EP1806154-A1, 2007Google Scholar
  104. 104.
    R. Mongrain, O.F. Bertrand, S. Yue, and O. Bertrand, Intermixed Particulate Material Used in Bioresorbable stent comprises cathodic Particles Made of Cathodic Material and Anodic Particles Made of Anodic Material Bound to Each Other, where the Materials Form a Galvanic Couple, WO2013163747-A1, 2013Google Scholar
  105. 105.
    P.A. Kramer, Preparing Medical Device e.g. Stent, Useful e.g. to Treat/Prevent Restenosis, Comprises Forming Porous Component Comprising Near Net-Shaped Device by e.g. Arc Wire Spray Process, US7854958-B2, 2010Google Scholar
  106. 106.
    J. Garcia-Forgas, P. Heinrich, H. Kreye, W. Kroemmer, A. Salito, and F.J. Garcia, Production of a Medical Implant for Joints Comprises Coating the Implant with a Particulate Material by Cold Gas Spraying, EP1864686-A1, 2007Google Scholar
  107. 107.
    R.B. Heimann, Plasma-Sprayed Hydroxylapatite-Based Coatings: Chemical, Mechanical, Microstructural, and Biomedical Properties, J. Therm. Spray Technol., 2016, 25(5), p 827-850CrossRefGoogle Scholar
  108. 108.
    R.B. Heimann and H.D. Lehmann, Bioceramic Coatings for Medical Implants, Wiley, New Yrok, 2015CrossRefGoogle Scholar
  109. 109.
    M. Driver, Coatings for Biomedical Applications, Woodhead Publishing Ltd, Sawston, 2012CrossRefGoogle Scholar
  110. 110.
    Y. Dong, P. Svoboda, M. Vrbka, D. Kostal, F. Urban, J. Cizek, P. Roupcova, H. Dong, I. Krupka, and M. Hartl, Towards Near-Permanent CoCrMo Prosthesis Surface by Combining Micro-Texturing and Low Temperature Plasma Carburising, J. Mech. Behav. Biomed. Mater., 2015, 55, p 215-227CrossRefGoogle Scholar
  111. 111.
    J. Cizek, V. Brozek, T. Chraska, F. Lukac, J. Medricky, R. Musalek, T. Tesar, F. Siska, Z. Antos, J. Cupera, M. Matejkova, Z. Spotz, S. Houdkova, and M. Kverka, Silver-Doped Hydroxyapatite Coatings Deposited by Suspension Plasma Spraying, J. Therm. Spray Technol., 2018. CrossRefGoogle Scholar
  112. 112.
    J. Cizek, I. Dlouhy, F. Siska, and K.A. Khor, Modification of Plasma-sprayed TiO2 Coatings Characteristics via Controlling the In-flight Temperature and Velocity of the Powder Particles, J. Therm. Spray Technol., 2014, 23(8), p 1339-1349CrossRefGoogle Scholar
  113. 113.
    K. Ravi, T. Deplancke, K. Ogawa, J.-Y. Cavaillé, and O. Lame, Understanding Deposition Mechanism in Cold Sprayed Ultra High Molecular Weight Polyethylene Coatings on Metals by Isolated Particle Deposition Method, Addit Manuf, 2018, 21, p 191-200CrossRefGoogle Scholar
  114. 114.
    C. Ning, L. Zhou, and G. Tan, Fourth-Generation Biomedical Materials, Mater. Today, 2016, 19(1), p 2-3CrossRefGoogle Scholar

Copyright information

© ASM International 2018

Authors and Affiliations

  1. 1.Institute of Plasma PhysicsThe Czech Academy of SciencesPragueCzech Republic

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