Mg-3Zn/HA Biodegradable Composites Synthesized via Spark Plasma Sintering for Temporary Orthopedic Implants
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In the present study, an attempt has been made to improve the mechanical properties, biocompatibility and degradation rate of Mg/3Zn matrix composite, by reinforcing with chemically inert and osteoconductive hydroxyapatite (HA). The composites were synthesized through spark plasma sintering for better consolidation. The HA content, in Mg/3Zn matrix, was optimized with an aim of improving mechanical behavior, corrosion resistance and biocompatibility simultaneously. It has been observed that reinforcement with 15 wt.% HA could slow down the corrosion rate by ~ 60% and improve the hardness and compression strength by ~ 42.8 and 18%, respectively. In vitro studies, up to 56 days, unveil the effect of HA reinforcement in corrosion resistance of magnesium-based matrix. Osteoblastic activity has shown better cell proliferation on the composite surfaces, which were reinforced with HA.
Keywordsbiodegradable hydroxyapatite in vitro corrosion magnesium orthopedic applications spark plasma sintering
DL acknowledges the financial support for funding by DST, India (SB/SO/HS/138/2013). Authors would also like to thank Department of Metallurgical and Materials Engineering, IIT Roorkee for maintaining experimental facilities. The authors would also like to acknowledge Dr. Naibedya Chattopadhyay of Central drug research institute (CDRI), India, for the Human Fetal Osteoblast Progenitor (hFOB) cell line. Thanks are extended to Mr. R Manoj Kumar and Ms. Ankita Bisht, research scholars in the Department of Metallurgical and Materials Engineering, IIT Roorkee, for their technical assistance during experiments. Authors are grateful to the laboratory staff of the Department of Biotechnology, IIT Roorkee, for cell culture facilities.
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