Metallurgical and Materials Transactions A

, Volume 49, Issue 11, pp 5888–5903 | Cite as

In Vitro Biodegradation and Mechanical Properties of Mg-Zn Alloy and Mg-Zn-Hydroxyapatite Composite Produced by Mechanical Alloying for Potential Application in Bone Repair

  • Emee Marina Salleh
  • Hussain ZuhailawatiEmail author
  • Siti Noor Fazliah Mohd Noor
  • Norinsan Kamil Othman


A biodegradable Mg-6.5 wt pct Zn (Mg-Zn) alloy and Mg-6.5 wt pct Zn reinforced with 10 wt pct hydroxyapatite (HA) composite were prepared by mechanical milling. In vitro biodegradation activity as a function of immersion time was performed in Hank’s balanced salt solution (HBSS). The dissolution of Mg ions (Mg2+) decreased from 75.74 µg/ml of pure Mg to 59.24 µg/ml and 46.88 µg/ml corresponding to the Mg-Zn alloy and Mg-Zn/HA composite, respectively. This finding indicates the progressive effect of HA followed by the Zn addition in decelerating the degradation rate of Mg. More positive corrosion potential of Mg-6.5 wt pct Zn alloy (− 1.5015 V) and Mg-Zn/10 wt pct HA composite (− 1.4647 V) than that of pure Mg (− 1.6972 V) suggested that the Mg-Zn/10 wt pct HA composite exhibited the highest corrosion resistance in the bioenvironment. The compressive strength values after 7 days of immersion in HBSS of the Mg-Zn alloy and Mg-Zn/HA composite are 230.64 and 278.46 MPa, respectively, and these are considerably higher compared to the compressive strength of the cortical bone (100 to 230 MPa).



The authors would like to thank Universiti Sains Malaysia RU-PRGS Grant No. 8046026, Malaysian Ministry of High Education (FRGS Grant No. 6071304) for the financial support.


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Copyright information

© The Minerals, Metals & Materials Society and ASM International 2018

Authors and Affiliations

  • Emee Marina Salleh
    • 1
  • Hussain Zuhailawati
    • 1
    Email author
  • Siti Noor Fazliah Mohd Noor
    • 2
  • Norinsan Kamil Othman
    • 3
  1. 1.Biomaterials Niche Area, School of Materials and Mineral Resources Engineering, Engineering CampusUniversiti Sains MalaysiaNibong TebalMalaysia
  2. 2.Cranofacial and Biomaterials Science Cluster, Advanced Medical and Dental InstituteUniversiti Sains MalaysiaKepala BatasMalaysia
  3. 3.School of Applied Physics, Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia (UKM)BangiMalaysia

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