Bone mineral density and its correlation with vitamin D status in healthy school-going children of Western India
Studies on vitamin D deficiency status and its impact on bone health in a developing country are limited. We assessed the bone mineral density and vitamin D levels in healthy school-going children of Western India. Around 65% children had vitamin D deficiency and vitamin D levels had good correlation with bone mineral density.
Vitamin D is an important substrate in the metabolism of calcium homeostasis and skeletal metabolism. Epidemiological studies on vitamin D deficiency status and its impact on bone mineral metabolism in healthy children in a developing country are limited. We assessed the bone mineral density and vitamin D levels in healthy school-going children of Western India.
We measured serum levels of 25-hydroxy vitamin D (25(OH)D) in healthy school-going children, aged 60 to 120 months. Dual-energy X-ray absorptiometry scan was done to assess the bone mineral density (BMD). The BMD status was compared with the levels of 25(OH)D and serum parathormone hormone in all the children.
A total of 100 school-going children were examined for evidence of vitamin D deficiency and 65% had deficiency (less than 50 nmol/L). The mean age was 90 months in males and 89 months in females. In the vitamin D-deficient group, the mean BMD (gm/cm2) measurements for the lumbar spine was 0.439 ± 0.098 (p < 0.001) and the mean BMD (gm/cm2) in the normal group was 0.606 ± 0.071 (p < 0.001). Pearson’s and Spearman’s rank correlation coefficients between vitamin D levels and BMD z score showed a significant positive correlation (r = 0.82, ρ = 0.924).
We confirmed the high prevalence of vitamin D deficiency among healthy school-going children. The serum levels of vitamin 25(OH)D has a good correlation with bone mineral density.
KeywordsVitamin D deficiency Bone mineral density Bone mineral disease 25-Hydroxy vitamin D Nutrition Developing country
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