Archives of Osteoporosis

, 14:7 | Cite as

An unusual Chinese case of celiac disease presenting as hypocalcemia and low bone density

  • Kunling Wang
  • Changxin Jiang
  • Hongwei Jia
  • Xin Zhang
  • Zhijie Sun
  • Mei ZhuEmail author
Case Report


Celiac disease (CD) is an immune-mediated small intestinal enteropathy that is triggered by exposure to dietary gluten in genetically predisposed individuals [1]. The typical manifestations of CD are diarrhea, steatorrhea, and malabsorptive symptoms [2], and the main predisposing genes are HLA-DQ2 and HLA-DQ8 [3]. The estimated prevalence of CD in adults in the USA and Europe was 0.2 to 1% [4]. With differing prevalence to Caucasian populations, CD was thought to be rare in China. We report an unusual Chinese case of CD in an adult who presented with hypocalcemia and secondary hyperparathyroidism, without gastrointestinal manifestations.

Case report

A 40-year-old Chinese woman presented with a 1-year history of back pain and 4-month history of tetany and numbness in her fingers. She had no perioral anesthesia, joint pain, morning stiffness, or history of seizures. In the preceding 2 years, she reported 1–2 bowel movements per day and rarely had loose stools. No anorexia,...


Compliance with ethical standards

The study has been approved by the Ethics Committee of Tianjin Medical University General Hospital and has been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from the patient.

Conflicts of interest



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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2019

Authors and Affiliations

  • Kunling Wang
    • 1
  • Changxin Jiang
    • 2
  • Hongwei Jia
    • 1
  • Xin Zhang
    • 1
  • Zhijie Sun
    • 3
  • Mei Zhu
    • 1
    Email author
  1. 1.Department of Endocrinology and MetabolismTianjin Medical University General HospitalTianjinChina
  2. 2.Department of PathologyTianjin Medical University General HospitalTianjinChina
  3. 3.Department of Endocrinology and GastroenterologyTianjin Hongqiao HospitalTianjinChina

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