An unusual Chinese case of celiac disease presenting as hypocalcemia and low bone density
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Celiac disease (CD) is an immune-mediated small intestinal enteropathy that is triggered by exposure to dietary gluten in genetically predisposed individuals . The typical manifestations of CD are diarrhea, steatorrhea, and malabsorptive symptoms , and the main predisposing genes are HLA-DQ2 and HLA-DQ8 . The estimated prevalence of CD in adults in the USA and Europe was 0.2 to 1% . With differing prevalence to Caucasian populations, CD was thought to be rare in China. We report an unusual Chinese case of CD in an adult who presented with hypocalcemia and secondary hyperparathyroidism, without gastrointestinal manifestations.
A 40-year-old Chinese woman presented with a 1-year history of back pain and 4-month history of tetany and numbness in her fingers. She had no perioral anesthesia, joint pain, morning stiffness, or history of seizures. In the preceding 2 years, she reported 1–2 bowel movements per day and rarely had loose stools. No anorexia,...
Compliance with ethical standards
The study has been approved by the Ethics Committee of Tianjin Medical University General Hospital and has been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
Informed consent was obtained from the patient.
Conflicts of interest
- 1.Ludvigsson JF, Bai JC, Biagi F, Card TR, Ciacci C, Ciclitira PJ, Green PH, Hadjivassiliou M, Holdoway A, van Heel D, Kaukinen K, Leffler DA, Leonard JN, Lundin KE, McGough N, Davidson M, Murray JA, Swift GL, Walker MM, Zingone F, Sanders DS, BSG Coeliac Disease Guidelines Development Group, British Society of Gastroenterology (2014) Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology. Gut 63:1210–1228CrossRefGoogle Scholar
- 6.McNicholas BA, Bell M (2010) Coeliac disease causing symptomatic hypocalcaemia, osteomalacia and coagulapathy. BMJ Case Rep 2010Google Scholar