Prevalence of vitamin D deficiency in postmenopausal high- and low-energy fracture patient
- 137 Downloads
This study evaluated the prevalence of vitamin D deficiency in postmenopausal women with fractures and revealed a high prevalence of vitamin D deficiency regardless of whether the injury mechanism was high or low energy. However, the prescription rate of vitamin D supplementation was lower in the high-energy compared to the low-energy injury group.
The present study aimed to investigate the prevalence of vitamin D deficiency in postmenopausal women with fractures from low-energy and high-energy injuries and to determine differences in the prevalence of vitamin D deficiency and the rate of postoperative vitamin D supplementation between the two groups.
Medical records of postmenopausal women aged ≥ 50 years who presented with fractures were reviewed. One hundred and thirty-six patients were enrolled and divided into two groups according to the injury mechanism: low (107 patients) vs. high energy (29 patients). Thereafter, serum vitamin D levels, bone turnover markers, body mass index (BMI), bone mineral density, history of prior osteoporosis therapy and vitamin D supplementation, and postoperative prescription rates were compared between the two groups. Vitamin D deficiency was defined as < 20 ng/mL, insufficiency as 20–30 ng/mL, and sufficiency as 30–150 ng/mL.
The overall average vitamin D level was 22.6 ng/mL. The prevalence of vitamin D deficiency was 61.8%, and the rate of insufficiency was 14.7%, while only 23.5% of patients showed normal vitamin D levels. The prevalence of vitamin D deficiency was 60.7% and 65.5% in the low and high-energy groups (p = 0.673), respectively. BMI and other laboratory measurements were similar between the two groups.
Postoperative calcium and vitamin D supplementation was administered in 85.0% of patients with low-energy injury, as compared to 58.6% of those with high-energy injury (p = 0.003). Osteoporosis medication was also prescribed more frequently in the low-energy group than in the high-energy group (73.8% vs. 48.3%, p = 0.009). In both groups, prescription rates of calcium and vitamin D supplementation and osteoporosis medication increased after the occurrence of fracture.
Postmenopausal women with fractures have a high prevalence of vitamin D deficiency regardless of whether the mechanism of injury was high or low energy, but the prescription rate of vitamin D supplementation was lower in the high-energy than in the low-energy injury group.
KeywordsFracture Vitamin D Osteoporosis Treatment
Compliance with ethical standards
Conflicts of interest
Jun Seung Lee declares that he has no conflict of interest. Ji Wan Kim declares that this study was supported by research funding from Korean Society for Bone and Mineral Research.
- 1.Brown AJ, Dusso A, Slatopolsky E (1999) Vitamin D. Am J Phys 277:F157–F175Google Scholar
- 7.Dixon T, Mitchell P, Beringer T, Gallacher S, Moniz C, Patel S, Pearson G, Ryan P (2006) An overview of the prevalence of 25-hydroxy-vitamin D inadequacy amongst elderly patients with or without fragility fracture in the United Kingdom. Curr Med Res Opin 22:405–415. https://doi.org/10.1185/030079906X89810 CrossRefPubMedGoogle Scholar
- 15.Bergstrom U, Bjornstig U, Stenlund H, Jonsson H, Svensson O (2008) Fracture mechanisms and fracture pattern in men and women aged 50 years and older: a study of a 12-year population-based injury register, Umea, Sweden. Osteoporos Int 19:1267–1273. https://doi.org/10.1007/s00198-007-0549-z CrossRefPubMedGoogle Scholar
- 21.LeBoff MS, Hawkes WG, Glowacki J, Yu-Yahiro J, Hurwitz S, Magaziner J (2008) Vitamin D-deficiency and post-fracture changes in lower extremity function and falls in women with hip fractures. Osteoporos Int 19:1283–1290. https://doi.org/10.1007/s00198-008-0582-6 CrossRefPubMedPubMedCentralGoogle Scholar
- 23.Mechanick JI, Camacho PM, Cobin RH, Garber AJ, Garber JR, Gharib H, Petak SM, Rodbard HW, Trence DL, American Association of Clinical Endocrinologists (2010) American association of clinical endocrinologists protocol for standardized production of clinical practice guidelines--2010 update. Endocr Pract 16:270–283. https://doi.org/10.4158/EP.16.2.270 CrossRefPubMedGoogle Scholar