Archives of Osteoporosis

, 13:8 | Cite as

Investigating the bone mineral density in children with solid tumors in southern Iran: a case–control study

  • Forough Saki
  • Sezaneh Haghpanah
  • Tahereh Zarei
  • Mohammad Hossein Dabbaghmanesh
  • Gholamhossein Ranjbar Omrani
  • Mohammadreza BordbarEmail author
Original Article



Along with increasing childhood cancer survival, there is increasing concern about its chronic complications. We showed that 20.5 and 45.9% of children with solid tumors in southern Iran had low bone mass for chronological age in lumbar and femoral area, which was associated with serum ferritin and hemoglobin. 52.4% of these children had vitamin D deficiency, as well.


Along with increasing the childhood cancer survival, there is increasing concern about the chronic complications of the disease and the related therapies. This study aims to compare the vitamin D status and bone mineral apparent density (BMAD) of these children with healthy ones and assess some possible associated factors.


This case–control study enrolled 50 children with solid tumors and their age- and sex-matched controls. Dual-energy X-ray absorptiometry was used to assess bone mineral density. Body mass index, puberty, physical activity, sun exposure, and biochemical data were assessed.


52.4% of children with solid tumors had vitamin D deficiency, and there was no significant difference between the prevalence of vitamin D deficiency in patients and controls (P = 0.285). The prevalence of low bone mass for chronological age in lumbar area was 20.5 and 12.5% in patients and controls, respectively (P = 0.399). Lumbar spine BMD was associated with hemoglobin level (r = 0.468, P = 0.049), while low bone mass in femoral neck was associated with serum ferritin (859 ± 1037 in low bone mass vs. 178 ± 264 in without low bone mass, P = 0.039).


Vitamin D deficiency and low bone mass are prevalent among Iranian children with solid tumors. Future studies are warranted to investigate the best strategies to prevent and treat vitamin D deficiency and low bone mass in children surviving cancer.


Low bone mass Children Iran Solid tumors Vitamin D 



We would like to thank Ms. R. Farmani for English editing and Ms. Sh. Parand for helping us to prepare the manuscript.

Compliance with ethical standards

Conflict of interest



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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2018

Authors and Affiliations

  • Forough Saki
    • 1
  • Sezaneh Haghpanah
    • 2
  • Tahereh Zarei
    • 2
  • Mohammad Hossein Dabbaghmanesh
    • 1
  • Gholamhossein Ranjbar Omrani
    • 1
  • Mohammadreza Bordbar
    • 2
    Email author
  1. 1.Shiraz Endocrinology and Metabolism Research CenterShiraz University of Medical SciencesShirazIran
  2. 2.Hematology Research CenterShiraz University of Medical SciencesShirazIran

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