Archives of Osteoporosis

, 13:11 | Cite as

Bone metabolism markers and vitamin D in adolescent cyclists

  • Hugo Olmedillas
  • Alejandro Gonzalez-Agüero
  • Marta Rapún-López
  • Luis Gracia-Marco
  • Alba Gomez-Cabello
  • Francisco Pradas de la Fuente
  • Luís A. Moreno
  • José A. Casajús
  • Germán Vicente-RodríguezEmail author
Original Article



This study aimed to describe bone metabolic activity in adolescent competitive cyclists compared to age-matched controls. The main result is that younger subjects present a higher bone turnover than the older ones. Moreover, cyclists under the age of 17 have higher scores on all markers than age-matched controls.


The purpose of this study was to describe bone metabolic activity in adolescent competitive cyclists compared to age-matched controls.


Twenty-two male adolescent cyclists between 14 and 20 years (y) and 20 age-matched controls participated in this study. Serum osteocalcin (OC), aminoterminal propeptide of type I procollagen (PINP), and β-isomerized C-telopeptides (β-CTX) were analyzed by electrochemiluminescence immunoassay (ECLIA); plasma 25 hydroxyvitamin D [25(OH)D] was analyzed by enzyme-linked immunosorbent assay (ELISA).


Analysis of variance revealed no significant differences in bone metabolism markers and vitamin D between cyclists and controls. Cyclists over 17 y had a significantly lower concentration in bone formation and resorption biochemical markers compared to cyclists under 17 y (all P < 0.05). Moreover, controls over 17 y presented lower concentration for PINP (P < 0.05) compared to their peers under 17 y. Comparisons between cyclists and controls under 17 y revealed higher concentrations of OC and PINP (P < 0.05) in cyclists. Group interaction by age was found for OC, PINP, and β-CTX (P < 0.01). Cyclists over 17 y had higher concentrations of [25(OH)D] (P < 0.05) than age-matched controls.


The present results support the idea that cycling during adolescence may be associated to a decrease in bone turnover that may affect bone health later in life.


Cyclists Adolescence Bone turnover Osteocalcin Vitamin D 



We wish to thank the controls, cyclists, and their coaches for their diligence and cooperation throughout this study.


This study has been funded by Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (DPS2008-06999); Presidencia del Gobierno de España, Consejo Superior de Deportes (21/UPB20/10); and Fondo Europeo de Desarrollo Regional (MICINN-FEDER).

Compliance with ethical standards

Written informed consent was obtained from parents and adolescents. The study was performed following the ethical guidelines of the Declaration of Helsinki 1961 (2000 Edinburgh revision). The Ethics Committee of Clinical Research for the Government of Aragón (CEICA; Spain) approved the study protocol.


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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2018

Authors and Affiliations

  • Hugo Olmedillas
    • 1
  • Alejandro Gonzalez-Agüero
    • 2
    • 3
    • 4
    • 5
    • 6
  • Marta Rapún-López
    • 7
  • Luis Gracia-Marco
    • 2
    • 8
  • Alba Gomez-Cabello
    • 2
    • 4
    • 5
    • 6
    • 9
  • Francisco Pradas de la Fuente
    • 7
  • Luís A. Moreno
    • 2
    • 4
    • 5
    • 6
    • 10
  • José A. Casajús
    • 2
    • 3
    • 4
    • 5
    • 6
  • Germán Vicente-Rodríguez
    • 2
    • 3
    • 4
    • 5
    • 6
    Email author
  1. 1.Department of Functional BiologyUniversidad de Oviedo, Campus del Cristo B. Julián Clavería s/nAsturiasSpain
  2. 2.GENUD (Growth, Exercise, NUtrition and Development) Research GroupUniversidad de ZaragozaZaragozaSpain
  3. 3.Faculty of Health and Sport Sciences (FCSD), Department of Physiatry and NursingUniversity of ZaragozaHuescaSpain
  4. 4.Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn)Santiago de CompostelaSpain
  5. 5.Instituto Agroalimentario de Aragón (IA2)ZaragozaSpain
  6. 6.Instituto de Investigación Sanitaria de Aragón (IIS Aragón)ZaragozaSpain
  7. 7.Departamento de Expresión Musical, Plástica y Corporal, Facultad de Ciencias de la Salud y del DeporteUniversidad de ZaragozaHuescaSpain
  8. 8.PROFITH “PROmoting FITness and Health through physical activity” Research Group, Department of Physical Education and Sports, Faculty of Sport SciencesUniversity of GranadaGranadaSpain
  9. 9.Centro Universitario de la DefensaZaragozaSpain
  10. 10.Facultad de Ciencias de la SaludUniversidad de ZaragozaZaragozaSpain

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