Altered Brain Regional Homogeneity Following Contralateral Acupuncture at Quchi (LI 11) and Zusanli (ST 36) in Ischemic Stroke Patients with Left Hemiplegia: An fMRI Study

  • Shu-qi Chen
  • De-chun Cai
  • Ji-xin Chen
  • Han Yang
  • Lian-sheng LiuEmail author
Acupuncture Research



To study the effect of contralateral acupuncture (CAT) at acupoints of Quchi (LI 11) and Zusanli (ST 36) on the unaffected limbs of ischemic stroke patients with left hemiplegia based on regional homogeneity (ReHo) indices.


Ten ischemic stroke patients with left hemiplegia received CAT on right side at LI 11 and ST 36. Functional magnetic resonance imaging (fMRI) was performed before and after acupuncture. A ReHo analytical method was used to compare brain responses of patients before and after CAT operated by REST software.


The stimulation at both LI 11 and ST 36 on the unaffected limbs produced significantly different neural activities. CAT elicited increased ReHo values at the right precentral gyrus and superior frontal gyrus, decreased ReHo value at right superior parietal lobule, left fusiform gyrus and left supplementary motor area.


Acupuncture at one side could stimulate bilateral regions. CAT could evoke the gyrus which was possibly related to motor recovery from stroke. A promising indicator of neurobiological deficiencies could be represented by ReHo values in post-stroke patients.


contralateral acupuncture ischemic stroke functional magnetic resonance imaging regional homogeneity 


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The authors would like to sincerely thank all participants, the physician assistant, and operators in MRI Room in the First Affiliated Hospital of Guangzhou University of Chinese Medicine.

Author Contributions

Liu LS and Chen SQ designed the experiment. Chen SQ drafted the manuscript. Liu LS made critical revision of the manuscript. Chen SQ, Cai DC, Chen JX, Yang H performed the experiment. Liu LS performed the data collection and analysis. All authors read and approved the final manuscript.

Conflict of Interest

All authors declare that they have no competing interests.

Supplementary material

11655_2019_3079_MOESM1_ESM.docx (76 kb)
Supplementary material, approximately 80 KB.


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Copyright information

© The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Shu-qi Chen
    • 1
    • 2
    • 3
  • De-chun Cai
    • 1
  • Ji-xin Chen
    • 4
  • Han Yang
    • 2
  • Lian-sheng Liu
    • 1
    Email author
  1. 1.Medical Imaging DepartmentThe First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina
  2. 2.Medical College of Acu-Moxi and RehabilitationGuangzhou University of Chinese MedicineGuangzhouChina
  3. 3.Artemisinin Research CenterGuangzhou University of Chinese MedicineGuangzhouChina
  4. 4.The Second Clinical CollegeGuangzhou University of Chinese MedicineGuangzhouChina

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