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Chinese Journal of Integrative Medicine

, Volume 25, Issue 11, pp 820–824 | Cite as

Impact of Jumihaidokuto (Shi-Wei-Bai-Du-Tang) on Treatment of Chronic Spontaneous Urticaria: A Randomized Controlled Study

  • Hiroyuki MurotaEmail author
  • Hiroaki Azukizawa
  • Ichiro Katayama
Original Article

Abstract

Objective

To study the effect of Jumihaidokuto (Shi-Wei-Bai-Du-Tang, 十味败毒汤) in the management of chronic spontaneous urticaria.

Methods

A randomized two-arm, parallel group study was conducted to compare the effect of Jumihaidokuto (6 g daily) with a control for 8 weeks. Concomitant therapy (e.g., antihistamines) was continued. Twenty-one subjects with severe chronic urticaria were enrolled in this study. The primary treatment outcome was the severity score proposed by the Japanese Dermatological Association. Secondary outcomes were quality of life (Skindex-16), itch intensity (Visual Analogue Scale), and patients’ subjective disability due to wheal or itch. After the subjects were randomly assigned to groups by block randomization, 10 received Jumihaidokuto, and 11 did not. All subjects had already taken antihistamines.

Results

Improvement was significant when comparing the severity score of the Jumihaidokuto group with that of the control group (P<0.01). Skindex-16 values for both groups gradually decreased in the same fashion.

Conclusion

Concomitant use of Jumihaidokuto with antihistamine was more effective than antihistamine alone in the management of chronic idiopathic urticaria. (Trial Registration No. UMIN000007251)

Keywords

Jumihaidokuto crude drug extract Shiwei Baidu Decoction Chinese medicine antihistamine chronic spontaneous urticaria severity quality of life 

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Notes

Author Contributions

KI and HM had made study protocol. KI had randomized the study subjects. HA and HM had contributed to intervention, and accumulated the clinical data. HM performed statistical analysis and wrote this manuscript.

Supplementary material

11655_2017_2950_MOESM1_ESM.pdf (113 kb)
Supplementary material to “Impact of Jumihaidokuto (Shi-Wei-Bai-Du-Tang) on Treatment of Chronic Spontaneous Urticaria: A Randomized Controlled Study”

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Copyright information

© The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Hiroyuki Murota
    • 1
    Email author
  • Hiroaki Azukizawa
    • 1
  • Ichiro Katayama
    • 1
  1. 1.Department of Dermatology, Course of Integrated Medicine, Graduate School of MedicineOsaka UniversitySuita, OsakaJapan

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