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Innesti di cellule staminali mesenchimali nelle grandi perdite di sostanza

  • G. Toro
  • L. Prinzo
  • M. Gison
  • C. Di Fino
  • A. De Cicco
  • A. Braile
  • F. Lepore
  • A. ToroEmail author
  • A. Schiavone Panni
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The use of mesenchymal stem cells in severe bone loss

Abstract

Severe bone loss is a critical issue in trauma and it requires complex techniques to preserve limb form and function. Regenerative medicine, using stem cells and molecular biology, might be useful to enhance bone healing in severe bone loss. Between 2017 and 2018, 4 patients showed severe bone loss. In all of them, the use of stem cells was added to fixation with a cortical graft. Fracture healing occurred in a range of 3 to 8 months. In our experience, the use of stem cells, in association with bone graft and stable fixation, was able to achieve bone healing even in case of severe bone loss.

Notes

Conflitto di interesse

Gli autori G. Toro, L. Prinzo, M. Gison, C. Di Fino, A. De Cicco, A. Braile, F. Lepore, A. Toro e A. Schiavone Panni dichiarano di non aver alcun conflitto d’interesse.

Consenso informato e conformità agli standard etici

Tutte le procedure descritte nello studio e che hanno coinvolto essere umani sono state attuate in conformità alle norme etiche stabilite dalla dichiarazione di Helsinki del 1975 e successive modifiche. Il consenso informato è stato ottenuto da tutti i pazienti inclusi nello studio.

Human and Animal Right

L’articolo non contiene alcuno studio eseguito su esseri umani e su animali da parte degli autori.

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Copyright information

© Società Italiana Ortopedici Traumatologi Ospedalieri d’Italia 2019

Authors and Affiliations

  • G. Toro
    • 1
    • 2
  • L. Prinzo
    • 3
  • M. Gison
    • 3
  • C. Di Fino
    • 1
  • A. De Cicco
    • 1
  • A. Braile
    • 1
  • F. Lepore
    • 1
  • A. Toro
    • 3
    Email author
  • A. Schiavone Panni
    • 1
  1. 1.U.O. Ortopedia, D.A.I. di Ortopedia, Riabilitazione e OdontoiatriaA.O.U. Università degli Studi della Campania “Luigi Vanvitelli”NapoliItalia
  2. 2.Dipartimento di scienze cliniche e medicina traslazionaleUniversità degli Studi di Roma “Tor Vergata”RomaItalia
  3. 3.U.O.C. Ortopedia e TraumatologiaOspedale “Villa Malta”SarnoItalia

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