Advertisement

Le cellule staminali mesenchimali nel trattamento delle pseudoartrosi

  • Maria RizzoEmail author
  • Luigi RomanoEmail author
  • Nicola Tammaro
Aggiornamenti
  • 1 Downloads

Use of mesenchimal stem cells in nonunions

Abstract

Bone regeneration is a complex physiological process of bone formation, which can be seen during normal fracture healing. However, there are clinical conditions in which failure of the biological processes of fracture-healing is evident, such as with nonunion. Many biological treatments to prevent or treat nonunions are emerging in clinical use, including stem-cell treatment: there is evidence showing that mesenchymal stromal cells (MSC) may constitute a potential therapeutic strategy to induce bone regeneration.

Notes

Conflitto di interesse

Gli autori Maria Rizzo, Luigi Romano e Nicola Tammaro dichiarano di non aver alcun conflitto d’interesse.

Consenso informato e conformità agli standard etici

Tutte le procedure descritte nello studio e che hanno coinvolto essere umani sono state attuate in conformità alle norme etiche stabilite dalla dichiarazione di Helsinki del 1975 e successive modifiche. Il consenso informato è stato ottenuto da tutti i pazienti inclusi nello studio.

Human and animal rights

L’articolo non contiene alcuno eseguito su esseri umani e su animali da parte degli autori.

Bibliografia

  1. 1.
    Giannoudis PV, Einhorn TA, Marsh D (2007) Fracture healing: the diamond concept. Injury 38:S3–S6 CrossRefGoogle Scholar
  2. 2.
    Andrzejowski P, Giannoudis PV (2019) The “diamond concept” for long bone non-union management. Orthop Traumatol 20:21–34 Google Scholar
  3. 3.
    Clancey GJ, Hansen ST (1978) Open fractures of the tibia: a review of one hundred and two cases. J Bone Jt Surg 60:118–122 CrossRefGoogle Scholar
  4. 4.
    Zelle BA, Bhandari M, Espiritu M et al. (2006) Evidence-Based Orthopaedic Trauma Working Group. Treatment of distal tibia fractures without articular involvement: a systematic review of 1125 fractures. J Orthop Trauma 20:76–79 CrossRefGoogle Scholar
  5. 5.
    Phieffer LS, Goulet JA (2006) Delayed unions of the tibia. J Bone Jt Surg 88:206–216 CrossRefGoogle Scholar
  6. 6.
    Goulet JA, Senunas LE, DeSilva GL, Greenfield ML (1997) Autogenous iliac crest bone graft. Complications and functional assessment. Clin Orthop Relat Res 339:76–81 CrossRefGoogle Scholar
  7. 7.
    Younger EM, Chapman MW (1989) Morbidity at bone graft donor sites. J Orthop Trauma 3:192–195 CrossRefGoogle Scholar
  8. 8.
    Prockop DJ (1997) Marrow stromal cells as stem cells for non hematopietic tissues. Science 276:71–74 CrossRefGoogle Scholar
  9. 9.
    Friedenstein AJ, Gorskaja JF, Kulagina NN (1976) Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol 4:267–274 Google Scholar
  10. 10.
    Weber BG, Cech O (1976) Pseudarthrosis: Pathophysiology, Biomechanics, Therapy, Results. Grune and Stratton, New York Google Scholar
  11. 11.
    Qu Z, Fang G, Cui Z, Liu Y (2015) Cell therapy for bone nonunion: a retrospective study. Minerva Med 106:315–321 Google Scholar
  12. 12.
    Griffin M, Iqbal SA, Bayat A (2011) Exploring the application of mesenchymal stem cells in bone repair and regeneration. J Bone Jt Surg 93:427–434 CrossRefGoogle Scholar
  13. 13.
    Dimitriou R, Jones E, McGonagle D, Giannoudis PV (2011) Bone regeneration: current concepts and future directions. BMC Med 9:66–75 CrossRefGoogle Scholar
  14. 14.
    Romeo P, Gigliotti S, Notarnicola A et al. (2017) Terapia con onde d’urto extracorporee nei disturbi del consolidamento osseo. Basi biologiche e raccomandazioni operative. G Ital Ortop Traumatol 43:205–210 Google Scholar
  15. 15.
    Fayaz H, Giannoudis P, Vrahas M et al. (2011) The role of stem cells in fracture healing and nonunion. Int Orthop 35:1587–1597 CrossRefGoogle Scholar
  16. 16.
    Forraz N, McGuckin CP (2011) The umbilical cord: a rich and ethical stem cell source to advance regenerative medicine. Cell Prolif 44:60–69 CrossRefGoogle Scholar
  17. 17.
    Devine SM, Bartholomew AM Mahmud N et al. (2001) Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion. Exp Hematol 29:244–255 CrossRefGoogle Scholar
  18. 18.
    Horwitz EM, Gordon PL, Koo WK et al. (2002) Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone. Proc Natl Acad Sci USA 99:8932–8937 CrossRefGoogle Scholar
  19. 19.
    Schrepfer S, Deuse T, Reichenspurner H et al. (2007) Stem cell transplantation: the lung barrier. Transplant Proc 39:573–576 CrossRefGoogle Scholar
  20. 20.
    Xue G, He M, Zhao J et al. (2011) Intravenous umbilical cord mesenchymal stem cell infusion for the treatment of combined malnutrition nonunion of the humerus and radial nerve injury. Regen Med 6:733–741 CrossRefGoogle Scholar
  21. 21.
    Lin Y, Wang T, Wu L et al. (2007) Ectopic and in situ bone formation of adipose tissue-derived stromal cells in biphasic calcium phosphate nanocomposite. J Biomed Mater Res 81:900–910 CrossRefGoogle Scholar
  22. 22.
    Emadedin M, Labibzadeh N, Fazeli R et al. (2017) Percutaneous autologous bone marrow-derived mesenchymal stromal cell implantation is safe for reconstruction of human lower limb long bone atrophic nonunion. Cell J 19:159–165 Google Scholar
  23. 23.
    Giannotti S, Trombi L, Bottai V et al.(2013) Use of autologous human mesenchymal stromal cell/fibrin clot constructs in upper limb non-unions: long-term assessment. PLoS ONE 8(8):e73893 CrossRefGoogle Scholar
  24. 24.
    Centeno CJ, Al-Sayegh H, Freeman MD et al. (2016) A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions. Int Orthop 40:1755–1765 CrossRefGoogle Scholar
  25. 25.
    Marcacci M, Kon E, Moukhachev V et al. (2007) Stem cells associated with macroporous bioceramics for long bone repair: 6- to 7-year outcome of a pilot clinical study. Tissue Eng 13:947–955 CrossRefGoogle Scholar
  26. 26.
    Bhargava R, Sankhla SS, Gupta A et al. (2007) Percutaneous autologous bone marrow injection in the treatment of delayed or nonunion. Indian J Orthop 41:67–71 CrossRefGoogle Scholar
  27. 27.
    Paley D, Young MC, Wiley AM et al. (1986) Percutaneous bone marrow grafting of fracture and bony defects. An experimental study in rabbits. Clin Orthop Relat Res 208:300–312 Google Scholar
  28. 28.
    Connolly JF, Guse R, Tiedeman J, Dehne R (1991) Autologous marrow injection as a substitute for operative grafting of tibial non unions. Clin Orthop Relat Res 266:259–270 Google Scholar

Copyright information

© Società Italiana Ortopedici Traumatologi Ospedalieri d’Italia 2019

Authors and Affiliations

  1. 1.Dipartimento di Sanità Pubblica, U.O.C. di Ortopedia e TraumatologiaUniversità “Federico II”NapoliItalia
  2. 2.Dipartimento di Scienze Chirurgiche, S.C. di Ortopedia e TraumatologiaP.O. SantobonoNapoliItalia
  3. 3.Scuola di Specializzazione in Ortopedia e TraumatologiaUniversità “Luigi Vanvitelli”NapoliItalia

Personalised recommendations