Chronic Conditions in Advanced Cardiac Disease: A Cluster Analysis of Transcatheter Aortic Valve Replacement (TAVR)-Treated Patients

  • Benjamin S. WesslerEmail author
  • Benjamin C. Koethe
  • Paul K. J. Han
  • Andrew R. Weintraub
  • James E. Udelson
  • Cynthia M. Boyd
  • David M. Kent
Concise Research Report


Transcatheter aortic valve replacement (TAVR) has revolutionized the care of older adults with symptomatic aortic stenosis, enabling treatment where once there was none.1 One third of these high-risk patients remain severely symptomatic or die 1 year after treatment and half of all deaths are due to non-cardiac causes.2 TAVR patients provide a unique opportunity to study multiple chronic conditions (MCC) for older adults with advanced cardiovascular disease (CVD). Here, we examine patterns of MCC present at the time of treatment and explore associations with short- and long-term patient-centered outcomes.


Retrospective analysis of claims data from the OptumLabs® Data Warehouse (OLDW) includes de-identified claims data for privately insured and Medicare Advantage enrollees in a large, private, US health plan. The database contains longitudinal health information on enrollees, representing a diverse mixture of ages, ethnicities, and geographical regions across the...



Authors would like to thanks Jason Nelson MPH for assistance with the OptumLabs analysis.

Funding Information

The study funded by K23 AG055667 (NIH-NIA), R03 AG056447 (NIH-NIA), K24 AG056578 (NIH-NIA), Bellows Foundation Grant, and American College of Cardiology (Washington, D.C).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they do not have a conflict of interest.


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Copyright information

© Society of General Internal Medicine 2020

Authors and Affiliations

  1. 1.Division of CardiologyTufts Medical CenterBostonUSA
  2. 2.Predictive Analytics and Comparative Effectiveness (PACE) CenterTufts Medical CenterBostonUSA
  3. 3.OptumLabs Visiting FellowSanta MonicaUSA
  4. 4.Center for Outcomes Research and EvaluationMaine Medical CenterPortlandUSA
  5. 5.Johns Hopkins School of Medicine Division of Geriatric Medicine and GerontologyBaltimoreUSA

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