Trends in Prevalence of Nonalcoholic Fatty Liver Disease in US Adults with Prediabetes
Prediabetes affects 84 million US adults, more than 50% of whom will develop diabetes in 15 years.1 Once patients develop diabetes, up to 75% will have nonalcoholic fatty liver disease (NAFLD), and many of these will develop nonalcoholic steatohepatitis (NASH) and advanced fibrosis.2 However, the burden of NAFLD and associated comorbidities in patients with prediabetes is less well understood. We aimed to estimate the population-based trends in prevalence of concurrent suspected NAFLD, advanced fibrosis and NASH cirrhosis in US adults with prediabetes.
We conducted a cross-sectional, retrospective cohort analysis of the 2003–2014 National Health and Nutrition Examination Survey (NHANES). We included people aged ≥ 18 years who had a HbA1C from 5.7 to 6.4% or fasting plasma glucose from 100 to 125 mg/dL, or who were told they had prediabetes by a doctor but had never been diagnosed with diabetes. Patients with other causes of liver disease: viral hepatitis, excess...
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Conflict of Interest
Dr. Alkhouri received research funding from Gilead, Intercept, Allergan, Cirius, Madrigal, and Genfit which was not related to this study. Dr. McCullough was supported by grant U01 DK061732. All other authors have no conflicts of interest.