Inappropriate Fluoroquinolone Use in Academic and Non-academic Primary Care Clinics
Within the USA, it is estimated that 30% of outpatient antibiotic prescriptions may be inappropriate.1 In 2016, the Centers for Disease Control and Prevention released the Core Elements of Outpatient Antibiotic Stewardship, which recommended clinicians and facilities perform tracking and reporting of antibiotic prescribing as an initiative to develop outpatient antibiotic stewardship programs (ASPs) and reduce inappropriate antibiotic use.2 Fluoroquinolones are a class of broad-spectrum antibiotics that are over-utilized in the outpatient setting with several recent Food and Drug Administration warnings for serious adverse drug reactions (ADRs).3, 4 An estimated 5.1% and 19.9% of fluoroquinolone prescriptions are for indications not requiring antibiotics or have indications with alternative first-line antibiotics, respectively.5 One study demonstrated 84.0% of outpatient fluoroquinolone prescriptions were inappropriate based on guideline recommendations.6The purpose of...
Department of Pharmacy and Drug Information, Grady Health System
Compliance with Ethical Standards
This study was granted exemption by the Emory University IRB and for this type of study formal consent is not required.
Conflict of Interest
The authors declare that they do not have a conflict of interest.
- 3.U.S. Food and Drug Administration. FDA warns about increased risk of ruptures or tears in the aorta blood vessel with fluoroquinolone antibiotics in certain patients. Available at: https://www.fda.gov/drugs/drug-safety-and-availability/fda-warns-about-increased-risk-ruptures-or-tears-aorta-blood-vessel-fluoroquinolone-antibiotics. Accessed April 29, 2019.
- 4.U.S. Food and Drug Administration. FDA reinforces safety information about serious low blood sugar levels and mental health side effects with fluoroquinolone antibiotics; requires label changes. Available at: https://www.fda.gov/drugs/drug-safety-and-availability/fda-reinforces-safety-information-about-serious-low-blood-sugar-levels-and-mental-health-side. Accessed April 29, 2019.