Journal of General Internal Medicine

, Volume 34, Issue 8, pp 1390–1391 | Cite as

Frailty and Acute Kidney Injury: a 1-Year Follow-up of a Prospective Cohort

  • Sarah Morton
  • Alexander Isted
  • Pascale Avery
  • Joe WangEmail author
Concise Research Reports


The demand that acute kidney injury (AKI) places on the healthcare system is well documented, with both increased morbidity and mortality.1 The Clinical Frailty Score (CFS) is a tool developed to assess an individual’s level of frailty and we have previously demonstrated an association between CFS and AKI.2 At 2 weeks following an acute medical admission, there is a higher mortality in those who are both “severely frail” (a frailty score of 7 to 9) and have an AKI on presentation than those who are frail or have AKI in isolation.3 However, there is currently no information regarding longer term outcomes in this group. We present 1-year follow-up data for our prospective cohort.3


This was a single-centre prospective cohort study. The 2-week data has been previously published.3Data were collected on unselected acute medical admission and takes over 12 non-consecutive days in June–July 2017. All patients aged ≥ 65 were included and given a CFS based on preadmission...


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Conflict of Interest

The authors declare that they do not have a conflict of interest.


  1. 1.
    Waikar SS, Liu KD, Chertow GM. Diagnosis, epidemiology and outcomes of acute kidney injury. Clin J Am Soc Nephrol 2008;3:844–61.CrossRefGoogle Scholar
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    Rockwood K, Song XW, MacKnight C, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005;173:489–95.CrossRefGoogle Scholar
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    Morton S, Isted A, Avery P, Wang J. Is frailty a predictor of outcomes in elderly inpatients with acute kidney injury? A prospective cohort study. Am J Med 2018;131:1231–56.CrossRefGoogle Scholar
  4. 4.
    Khwaja A. KDIGO Clinical Practice Guidelines for Acute Kidney Injury. Nephron Clin Pract 2012;120:C179-C84.PubMedGoogle Scholar

Copyright information

© Society of General Internal Medicine 2019

Authors and Affiliations

  • Sarah Morton
    • 1
  • Alexander Isted
    • 1
  • Pascale Avery
    • 1
  • Joe Wang
    • 1
    • 2
    Email author
  1. 1.St George’s HospitalLondonUK
  2. 2.Acute Medicine and Nephrology Epsom and St Helier University Hospital NHS TrustCarshaltonUK

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