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A Systematic Review of Intra-pancreatic Fat Deposition and Pancreatic Carcinogenesis

  • Uma L. Sreedhar
  • Steve V. DeSouza
  • Brittany Park
  • Maxim S. PetrovEmail author
Original Article
  • 31 Downloads

Abstract

Background

Excess adiposity is considered causally related to pancreatic cancer. While most knowledge on the topic comes from studies on general and visceral adiposity, the role of intra-pancreatic fat deposition in pancreatic carcinogenesis just begins to be elucidated. The aim was to conduct a comprehensive systematic review of clinical studies on intra-pancreatic fat deposition in individuals with pancreatic cancer or pre-malignant lesions.

Methods

A literature search was conducted independently by two reviewers using three electronic databases. Studies were included if they reported on intra-pancreatic fat deposition determined based on modern radiology or histology. Summary estimates were presented as pooled prevalence or relative risk and 95% confidence interval.

Results

A total of 13 studies (encompassing 2178 individuals) were included. The pooled prevalence of intra-pancreatic fat deposition in individuals with pancreatic cancer or pre-malignant lesions was 52% (95% confidence interval, 38–66%). The presence of pancreatic cancer or pre-malignant lesions was associated with a significantly increased risk of intra-pancreatic fat deposition (relative risk 2.78 (95% confidence interval, 1.56–4.94, p < 0.001).

Conclusion

Individuals with pancreatic cancer or pre-malignant lesions are characterized by increased intra-pancreatic fat deposition. There are sound grounds for conceptually viewing intra-pancreatic fat deposition as a combination of fat accumulation in the pancreas (due to expansion of excess visceral fat) and fatty replacement of the pancreas (due to changes in cellular identity within the pancreas). Guidelines on reporting intra-pancreatic fat deposition need to be developed with a view to informing a comprehensive and standardized characterization of this clinical entity in future studies.

Keywords

Pancreatic cancer Pancreatic pre-malignant lesions Intra-pancreatic fat deposition Imaging Histology Systematic review 

Notes

Authors’ Contributions

Uma L. Sreedhar: data acquisition and analysis; drafting the manuscript; final approval of the manuscript; agreement to be accountable for all aspects of the work.

Steve V. DeSouza: data acquisition and analysis; revising the manuscript critically for important intellectual content; final approval of the manuscript; agreement to be accountable for all aspects of the work.

Brittany Park: data acquisition and analysis; revising the manuscript critically for important intellectual content; final approval of the manuscript; agreement to be accountable for all aspects of the work.

Maxim S. Petrov: conceived the study; supervised the study; revising the manuscript critically for important intellectual content; final approval of the manuscript; agreement to be accountable for all aspects of the work.

Funding Information

This study was part of the COSMOS program. COSMOS is supported, in part, by the Royal Society of New Zealand (Rutherford Discovery Fellowship to Associate Professor Max Petrov), which played no role in the study design; collection, analysis, interpretation of data, or writing of the manuscript.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Supplementary material

11605_2019_4417_MOESM1_ESM.doc (26 kb)
ESM 1 (DOC 26 kb)

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Copyright information

© The Society for Surgery of the Alimentary Tract 2019

Authors and Affiliations

  • Uma L. Sreedhar
    • 1
  • Steve V. DeSouza
    • 1
  • Brittany Park
    • 1
  • Maxim S. Petrov
    • 1
    • 2
    Email author
  1. 1.Department of SurgeryUniversity of AucklandAucklandNew Zealand
  2. 2.Auckland City HospitalAucklandNew Zealand

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