Prognostic Significance of Pre- and Post-operative Red-Cell Distribution Width in Patients with Gastric Cancer
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High red cell distribution width (RDW) is reportedly provoked by chronic inflammation and poor nutritional status; high pre-operative RDW is related to poor prognosis in some cancers. However, the prognostic significance of post-operative RDW in gastric cancer (GC) patients is unclear.
We enrolled 221 patients who had undergone curative surgery for histopathologically diagnosed gastric adenocarcinoma.
Optimal cutoff values were determined by ROC analysis to be 14.85 (pre-operative) and 14.05 (post-operative). We accordingly divided patients into the high (pre-RDWHigh; ≥ 14.85) and low (pre-RDWLow; < 14.85) pre-operative RDW groups, and the high (post-RDWHigh; ≥ 14.05) and low (post-RDWLow; < 14.05) post-operative RDW subgroups. Five-year overall survival (OS) rates differed significantly in pre-RDWHigh group (52.4%) and pre-RDWLow group (78.0%; P < 0.0001). Five-year OS rates also differed significantly in post-RDWHigh (52.7%) and post-RDWLow subgroups (88.3%; P < 0.0001). Multivariate analysis showed post-operative RDW, but not pre-operative RDW, to be an independent prognostic indicator for OS.
Post-operative RDW may be a useful prognostic indicator in GC patients.
KeywordsGastric cancer Prognosis Recurrence Red cell distribution width
We thank Marla Brunker from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.
Study conception and design: S; acquisition of data: M, S, K, M, S, M, and F; analysis and interpretation of data: S and S; drafting of manuscript: S, S, K, M, S, M, and F; critical revision: S and F; final approval of the article: all authors.
Compliance with Ethical Standards
Conflict of Interest
All authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Research Committee and with the 1964 Helsinki Declaration and its later amendments or with comparable ethical standards.
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