13N-NH3 PET/CT in oncological disease
13N-Ammonia (13N-NH3) is widely used positron emission tomography/computed tomography (PET/CT) radiotracer for the measurement of myocardial blood perfusion; the possible role of 13N-NH3 PET or PET/CT in oncological disease is not yet clear. Aim of this review is to evaluate the diagnostic performances of 13N-NH3 PET in this field. A comprehensive computer literature search of the PubMed/MEDLINE, Scopus, and Embase databases was conducted including articles up to June 2019. Eighteen articles were finally included in the review. From the analyses of the selected studies, the following main findings could be drawn: (1) 13N-NH3 PET is useful in discriminating between gliomas and non-neoplastic brain lesions, and among gliomas between high-grade and low-grade gliomas; (2) 13N-NH3 PET have better diagnostic performance than 18F-FDG in studying gliomas; (3) a combination of 13N-NH3 PET and 18F-FDG PET may be useful to differentiate between several cerebral lesions (gliomas, cerebral lymphoma, meningioma); (4) only preliminary results about the positive impact in liver and prostate cancer.
Keywords13N-NH3 PET/CT Oncological disease Review Glioma
Compliance with ethical standards
Conflict of interest
The authors declare they have no conflict of interest.
- 2.Sciagrà R, Milan E, Giubbini R, Kunik T, Di Dato R, Gallo L, et al. Sub-endocardial and sub-epicardial measurement of myocardial blood flow using 13NH3 PET in man. J Nucl Cardiol 2018. https://doi.org/10.1007/s12350-018-1445
- 4.Maddahi J, Packard RR. Cardiac PET perfusion tracers: current status and future directions. SeminNucl Med. 2014;44:333–43.Google Scholar
- 9.Cooper AJ, McDonald JM, Gelbard AS, Gledhill RF, Duffy TE. The metabolic fate of 13N-labeled ammonia in rat brain. J Biol Chem 1979;254:4982–92.Google Scholar
- 26.Shi X, Zhang X, Yi C, Liu Y, He Q. [13N]Ammonia positron emission tomographic/computed tomographic imaging targeting glutamine synthetase expression in prostate cancer. Mol Imaging. 2014;13:1–10.Google Scholar
- 33.Hu LS, Eschbacher JM, Dueck AC, Heiserman JE, Liu S, Karis JP, et al. Correlations between perfusion MR imaging cerebral blood volume, microvessel quantification, and clinical outcome using stereotactic analysis in recurrent high-grade glioma. AJNR Am J Neuroradiol. 2012;33:69–766.CrossRefGoogle Scholar
- 37.Akimoto J. Immunohistochemical study of glutamine synthetase expression in normal human brain and intracranial tumors. No ToShinkei. 1993;45:362–8.Google Scholar