Initial clinical experience of a prototype ultra-high-resolution CT for assessment of small intracranial arteries

  • Hiroyuki NagataEmail author
  • Kazuhiro Murayama
  • Shigetaka Suzuki
  • Ayumi Watanabe
  • Motoharu Hayakawa
  • Yasuo Saito
  • Kazuhiro Katada
  • Hiroshi Toyama
Original Article



Diagnostic and neurosurgical procedures require the precise localization of small intracranial arteries, but this may be difficult using conventional computed tomography angiography (CTA). This study was conducted to evaluate the quality of CTA images acquired using a prototype ultra-high-resolution computed tomography (U-HRCT) system compared with those acquired using a conventional computed tomography (C-CT) system.

Materials and methods

From July through September 2015, 10 adult patients (6 women and 4 men) previously scanned by C-CT were examined using U-HRCT to locate and assess cerebral aneurysms. The bilateral ophthalmic artery (Opth A), anterior choroidal artery (Acho A), and thalamoperforating arteries (TPAs) were visually evaluated in randomly presented CTA images. Images were graded on a 5-point scale, and differences in scores between U-HRCT and C-CT were evaluated by the Wilcoxon signed-rank test. A p value < 0.05 was considered statistically significant.


Visual evaluation scores for images of the Opth A, Acho A, and TPAs were significantly higher for U-HRCT than for C-CT. U-HRCT images achieved good visualization (score > 3) for C-CT images with poor visualization (score < 3) in 66.7–100% of all the small arteries.


U-HRCT is superior to C-CT for detecting and evaluating clinically significant small intracranial arteries.


Ultra-high-resolution computed tomography Small intracranial arteries Computed tomography angiography 



We received no financial support for this review article.

Compliance with ethical standards

Conflict of interest

Yasuo Saito is employees of Canon Medical Systems Corporation. Kazuhiro Katada is an advisor of Canon Medical Systems Corporation. The remaining authors declare that they have no conflict of interest.

Ethical statement

This article does not contain any studies with human participants or animals performed by any of the authors. This study received the approval of the institutional review board of our hospital.


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Copyright information

© Japan Radiological Society 2019

Authors and Affiliations

  1. 1.Department of RadiologyFujita Health UniversityToyoakeJapan
  2. 2.Department of NeurosurgeryFujita Health UniversityToyoakeJapan
  3. 3.CT Systems DivisionCanon Medical Systems CorporationTochigiJapan
  4. 4.Joint Research Laboratory of Advanced Medical ImagingFujita Health UniversityToyoakeJapan

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