Is Acupuncture Effective for Improving Insulin Resistance? A Systematic Review and Meta-analysis
This study aimed to evaluate the clinical efficacy of acupuncture for intervening insulin resistance (IR) by meta-analysis of related randomized controlled trials (RCTs). Studies published prior to 31 January 2018 were searched on Pubmed, Medline, Cochrane Library, Embase databases and Chinese databases. Only RCTs, which examined acupuncture as the sole or adjunctive treatment for IR-related diseases, were included. The primary outcome was homeostasis model assessment for insulin resistance (HOMA-IR). The secondary outcomes consisted of fasting blood glucose (FBG), fasting insulin (FINS) and 2-h postprandial blood glucose (2h-PBG). The differences between groups were reported as mean differences (MD). All statistical analyses were performed using RevMan software 5.3. After carefully screening relevant studies, 9 RCTs involving 562 patients (279 in experimental group and 283 in control group) were enrolled in this study. The pooled results showed that acupuncture had significant effects on HOMA-IR (MD 0.70, 95% CI 0.04 to 1.35, P=0.04<0.05), FINS (MD 3.35 mU/L, 95% CI 1.99 to 4.7, P<0.001) and 2h-PBG (MD 1.03 mmol/L, 95% CI 0.25 to 1.82, P=0.01). However, the differences in FBG were not significant (MD 0.28 mmol/L, 95% CI–0.28 to 0.84, P=0.32>0.05). The present meta-analysis indicated that acupuncture can help to improve IR to a certain extent, which remains to be confirmed by further high-quality RCTs.
Key wordsacupuncture insulin resistance randomized controlled trials meta-analysis
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- 12.Hao C, Zhang T, Qi J, et al. Acupuncture at Zhibian (BL 54) through Shuidao (ST 28) for polycystic ovary syndrome. Zhongguo Zhen Jiu (Chinese), 2015,35(5):461–464Google Scholar
- 15.Garcia-Vivas JM, Galaviz-Hernandez C, Becerril-Chavez F, et al. Acupoint catgut embedding therapy with moxibustion reduces the risk of diabetes in obese women. J Res Med Sci, 2014,19(7):610–616Google Scholar
- 17.Song AQ, Liang FX. Is acupuncture effective for improving insulin resistance? A systematic review and meta-analysis. PROSPERO: CRD42018088172 https://doi.org/www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=88172
- 18.Higgins JP, Green S. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0: The Cochrane Collaboration, 2011Google Scholar
- 19.Chen R, Wang C, Yan QY. Observation on therapeutic effect of polycystic ovary syndrome of damp-phlegm constitution treated with embedding therapy on backshu points and front-mu points combined with needlepricking therapy on Sifeng (EX-UE 10). Zhongguo Zhen Jiu (Chinese), 2014,34(4):355–358Google Scholar
- 20.Yang J, Liu Y, Huang J, et al. Acupuncture and Chinese medicine of artificial cycle therapy for insulin resistance of polycystic ovary syndrome with phlegm damp type and its mechanism. Zhongguo Zhen Jiu (Chinese), 2017,37(11):1163–1168Google Scholar
- 21.Cai H, Zhao LJ, Zhao ZM, et al. Effect of acupuncture on serum leptin level in patients with type II diabetes mellitus. Zhen Ci Yan Jiu (Chinese), 2011,36(4):288–291Google Scholar
- 22.Lin RT, Pai HC, Lee YC, et al. Electroacupuncture and rosiglitazone combined therapy as a means of treating insulin resistance and type 2 diabetes mellitus: A randomized controlled trial. Evid-based Compl Alt, 2013,2013:969824Google Scholar
- 23.Yang Y, Liu YX. BO's abdominal acupuncture for obese type-2 diabetes mellitus. Zhongguo Zhen Jiu (Chinese), 2015,35(4):330–334Google Scholar