Current Medical Science

, Volume 38, Issue 6, pp 1018–1024 | Cite as

DJ-1 Alters Epirubicin-induced Apoptosis via Modulating Epirubicinactivated Autophagy in Human Gastric Cancer Cells

  • Xue-kai Pan
  • Fei Su
  • Li-hua Xu
  • Zhang-shuo Yang
  • Dan-wen Wang
  • Li-jie Yang
  • Fan-zheng Kong
  • Wei Xie
  • Mao-hui FengEmail author


Epirubicin, which is a conventional chemotherapeutic drug for gastric cancer, has innate and adaptive chemoresistance. Recent studies revealed that epirubicin could induce autophagy as a defensive mechanism in drug resistance of mammary carcinoma. Another study implied that DJ-1 may be a chemoresistance-related gene. But the association between DJ-1 and drug resistance of epirubicin in gastric cancer is still ambiguous. In the present report, we explored whether and how DJ-1 conduced to epirubicin-induced apoptosis in gastric cancer. Epirubicin dose-dependently increased the expression of DJ-1 and induced autophagy. Knockdown of DJ-1 notably enhanced epirubicin-induced cell apoptosis, whereas overexpression of DJ-1 attenuated epirubicin-induced cell apoptosis. Further studies revealed that down-regulation of DJ-1 modulated epirubicinactivated autophagy which augmented epirubicin-induced apoptosis. In conclusion, our results validated that DJ-1 reduced epirubicin-induced apoptosis in gastric cancer cells via modulating epirubicin-activated autophagy.

Key words

epirubicin gastric cancer DJ-1 apoptosis autophagy 


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Copyright information

© Huazhong University of Science and Technology 2018

Authors and Affiliations

  • Xue-kai Pan
    • 1
  • Fei Su
    • 2
  • Li-hua Xu
    • 1
  • Zhang-shuo Yang
    • 1
  • Dan-wen Wang
    • 1
  • Li-jie Yang
    • 1
  • Fan-zheng Kong
    • 1
  • Wei Xie
    • 1
  • Mao-hui Feng
    • 1
    Email author
  1. 1.Department of Gastrointestinal SurgeryZhongnan Hospital of Wuhan UniversityWuhanChina
  2. 2.Department of Oncologythe First Hospital of Lanzhou UniversityLanzhouChina

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