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Current Medical Science

, Volume 38, Issue 5, pp 798–808 | Cite as

Predictive Values of Postoperative and Dynamic Changes of Inflammation Indexes in Survival of Patients with Resected Colorectal Cancer

  • Zi-quan Zhou
  • Shuo Pang
  • Xing-chen Yu
  • Qi Xue
  • Hong-yu Jiang
  • Xin-jun LiangEmail author
  • Li LiuEmail author
Article
  • 41 Downloads

Abstract

The aim of the present study was to evaluate the prognostic potential of postoperative scores of inflammation indexes and the dynamic changes of scores before and after tumor resection in colorectal cancer patients. The study included 516 colorectal cancer patients with primary colorectal tumor resection. Cox regression was applied to estimate the associations of postoperative and dynamic changes of inflammation indexes with progression-free survival and overall survival. As results, we found that higher postoperative neutrophil to lymphocyte ratio (NLR), neutrophil and monocyte to lymphocyte ratio (NMLR), platelet to lymphocyte ratio (PLR) and systemic immune inflammation index (SII) were associated with shorter progression-free survival. The increased NLR, NMLR, PLR, SII and C-reaction protein (CRP) to albumin (ALB) ratio (CAR) were associated with poor progression-free survival, with HRs (95% CIs) of 1.92 (1.27–2.90), 1.46 (1.11–2.09), 2.10 (1.34–3.30), 1.81 (1.22–2.70) and 1.65 (1.03–2.67), respectively. Postoperative NMLR, SII, CAR, and their dynamic changes were also significantly correlated with overall survival, with the HRs (95% CIs) of 2.63 (1.30–3.97), 2.44 (1.43–4.17), 2.74 (1.31–5.74), 2.08 (1.21–3.60), 1.97 (1.12–3.45) and 2.55 (1.21–5.38) respectively. In conclusion, postoperative inflammation indexes and their dynamic changes, particularly for NMLR, SII and CAR are promising prognostic predictors of CRC patients.

Key words

colorectal cancer postoperative inflammation index dynamic change prognosis 

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Copyright information

© Huazhong University of Science and Technology 2018

Authors and Affiliations

  1. 1.Department of Epidemiology and Biostatistics, the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of Medical OncologyHubei Cancer HospitalWuhanChina

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