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The Study of Nerve Conduit with Biocompatibility and Electrical Stimulation Effect

  • Xinglei Guo (郭兴蕾)
  • Gang Liu (刘刚)
  • Qundi He
  • Haixing Xu (徐海星)Email author
  • Yunxuan Yu
  • Changsheng Ke
  • Xiaofei Ming
  • Meng Zhao
  • Xiaobin Wang
  • Zhijun Huang
  • Peihu Xu (许沛虎)Email author
Organic Materials
  • 9 Downloads

Abstract

Conductive polymers show great promise because of their electrical property based on bioelectricity in vivo. In order to search electro-activity materials which insure abduction of tissue, we synthesized conductive nerve conduits with poly-dl-lactic-acid (PDLLA) and tetra-aniline (TA). Preparation technology of TA was optimized, and the properties of the conduit were studied. RSC96 cell were used to investigate the toxicity and electrical stimulation effect. SD rats were used to assess biocompatibility in vivo. The results showed that the reaction ratio of 1:1, the reaction time of 2 h and the HCl concentration of 2 mol/L were the optimum conditions for synthesis of TA. The influence of TA content on the mechanical properties, hydrophilicity, conductivity and microstructure of the nerve conduit was evaluated. Cell and histocompatibility study showed PDLLA/TA possessed good biocompatibility. These results showed it had application values in tissue projects.

Key words

nerve injury polymer poly-dl-lactic-acid tetra-aniline conduit 

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Copyright information

© Wuhan University of Technology and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Xinglei Guo (郭兴蕾)
    • 1
  • Gang Liu (刘刚)
    • 2
  • Qundi He
    • 3
  • Haixing Xu (徐海星)
    • 1
    Email author
  • Yunxuan Yu
    • 1
  • Changsheng Ke
    • 1
  • Xiaofei Ming
    • 1
  • Meng Zhao
    • 1
  • Xiaobin Wang
    • 4
  • Zhijun Huang
    • 1
  • Peihu Xu (许沛虎)
    • 1
    Email author
  1. 1.Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life SciencesWuhan University of TechnologyWuhanChina
  2. 2.Department of PharmacyRenmin Hospital of Wuhan UniversityWuhanChina
  3. 3.Wuhan Mafangshan Middle SchoolWuhanChina
  4. 4.Wuhan Kanghua Century Pharmaceutical CompanyWuhanChina

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