, Volume 25, Issue 6, pp 2835–2843 | Cite as

Synthesis of graphene/carbon nanofiber for electrochemical determination of levodopa in the presence of uric acid

  • Wan Qiu Wang
  • Hong Yan YueEmail author
  • Ze Min Yu
  • Shuo Huang
  • Shan Shan Song
  • Xin Gao
  • En Hao Guan
  • Hong Jie Zhang
  • Zhao Wang
Original Paper


Carbon nanofiber (CNF) was prepared by electrospinning using polypropylene and nickel was coated on the CNF by electroless plating. Then, graphene (Gr) was synthesized on the surface of nickel by chemical vapor deposition. After etching nickel, the Gr/CNF was obtained eventually and then used as a working electrode for the determination of levodopa in the presence of uric acid by cyclic voltammetry and differential pulse voltammetry. The morphology and structure were investigated by scanning electron microscopy and Raman spectroscopy, respectively. The results indicate that the electrode exhibits a high sensitivity of 0.26 μA·μM−1 and a low measured limit of detection of 1 μM for levodopa in the range of 1–60 μM. The electrode shows excellent selectivity, reproducibility, and stability. It was also applied to determine levodopa in the spiked human urine samples.


Carbon nanofiber Graphene Electroless plating Chemical vapor deposition Levodopa Uric acid 


Funding information

This work is supported by the Natural Science Foundation of Heilongjiang Province (LC2015020), Technology Foundation for Selected Overseas Chinese Scholar, Ministry of Personnel of China (2015192), the Innovative Talent Fund of Harbin city (2016RAQXJ185), and Science Funds for the Young Innovative Talents of HUST (201604).

Supplementary material

11581_2018_2801_MOESM1_ESM.doc (282 kb)
ESM 1 (DOC 281 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Wan Qiu Wang
    • 1
  • Hong Yan Yue
    • 1
    Email author
  • Ze Min Yu
    • 1
  • Shuo Huang
    • 1
    • 2
  • Shan Shan Song
    • 1
  • Xin Gao
    • 1
  • En Hao Guan
    • 1
  • Hong Jie Zhang
    • 1
  • Zhao Wang
    • 1
  1. 1.School of Materials Science and EngineeringHarbin University of Science and TechnologyHarbinPeople’s Republic of China
  2. 2.Department of NeurologyThe First Affiliated Hospital of Harbin Medical UniversityHarbinPeople’s Republic of China

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