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Voltammetric determination of dopamine in the presence of tyrosine using graphite screen-printed electrode modified with graphene quantum dots

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Abstract

Dopamine (DA) is an important neurotransmitter that belongs to the catecholamine group and plays a very significant role in the central nervous, renal, hormonal, and cardiovascular systems. As a result, dysfunction of the dopaminergic system in the central nervous system (CNS) has been related to neurological disorders such as schizophrenia and Parkinson’s disease. Therefore, in this work, a screen-printed electrode was modified by graphene quantum dots (GQD/SPE) in order to be used as sensor for dopamine in the presence of tyrosine. To evaluate the efficiency of the developed electrode toward detection of dopamine and tyrosine in aqueous solutions, various electrochemical methods including cyclic voltammetry (CV), chronoamperometry (CHA), and differential pulse voltammetry (DPV) techniques were employed. Application of GQD/SPE created a separation of 435 mV in the oxidation peak potentials of dopamine and tyrosine. The calibration curves were within the range of 0.1–1000.0 and 1.0–900.0 μM for dopamine and tyrosine, respectively. The detection limits (S/N = 3) were determined as 0.05 and 0.5 μM for dopamine and tyrosine, respectively. The diffusion coefficients using chronoamperometry at the surface of modified electrode were determined as 9.0 × 10−5 and 6.4 × 10−5 cm2 s−1 for dopamine and tyrosine, respectively.

Keywords

Graphene quantum dots Dopamine Tyrosine Differential pulse voltammetry sensing 

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Environment Department, Institute of Science and High Technology and Environmental SciencesGraduate University of Advanced TechnologyKermanIran
  2. 2.Department of ChemistryGraduate University of Advanced TechnologyKermanIran
  3. 3.Center of Excellence in Electrochemistry, Faculty of ChemistryUniversity of TehranTehranIran
  4. 4.Biosensor Research Center, Endocrinology & Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran
  5. 5.Department of Biotechnology, Institute of Science and High Technology and Environmental SciencesGraduate University of Advanced TechnologyKermanIran

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