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Cognitive Neurodynamics

, Volume 13, Issue 6, pp 531–540 | Cite as

Frontal–temporal functional connectivity of EEG signal by standardized permutation mutual information during anesthesia

  • Fahimeh Afshani
  • Ahmad ShalbafEmail author
  • Reza Shalbaf
  • Jamie Sleigh
Research Article
  • 70 Downloads

Abstract

Quantifying brain dynamics during anesthesia is an important challenge for understanding the neurophysiological mechanisms of anesthetic drug effect. Several single channel Electroencephalogram (EEG) indices have been proposed for monitoring anesthetic drug effect. The most commonly used single channel commercial index is the Bispectral index (BIS). However, this monitor has shown some drawbacks. In this study, a nonlinear functional connectivity measure named Standardized Permutation Mutual Information (SPMI) is proposed to describe communication between two-channel EEG signals at frontal and temporal brain regions during a controlled propofol-induced anesthesia and recovery design from eight subjects. The SPMI index has higher correlation with estimated propofol effect-site concentration and has better ability to distinguish three anesthetic states of patient than the other functional connectivity indexes (cross-correlation, coherence, phase analysis) and also the BIS index. Moreover, the SPMI index has a faster reaction to the effect of drug concentration, less variability at the consciousness state and better robustness to noise than BIS.

Keywords

Electroencephalogram Depth of anesthesia Mutual information Bispectral index 

Notes

References

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Fahimeh Afshani
    • 1
  • Ahmad Shalbaf
    • 2
    Email author
  • Reza Shalbaf
    • 3
  • Jamie Sleigh
    • 4
  1. 1.Department of Biomedical Engineering, Electronic BranchIslamic Azad UniversityTehranIran
  2. 2.Department of Biomedical Engineering and Medical Physics, School of MedicineShahid Beheshti University of Medical SciencesTehranIran
  3. 3.Institute for Cognitive Science StudiesTehranIran
  4. 4.Department of AnesthesiaWaikato HospitalHamiltonNew Zealand

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