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What Counts as “Success” in Speculative and Anticipatory Ethics? Lessons from the Advent of Germline Gene Editing

  • Ari SchickEmail author
Discussion Note


This discussion note offers a preliminary analysis of what recent developments in human germline gene editing tell us about the effectiveness of speculative and anticipatory modes of techno-ethics. It argues that the benefits of speculative discussions are difficult to detect thus far, and that pushing the focal point of ethical discourse well ahead of the current state of technology may prematurely undermine existing norms long before a broad consensus would justify moving beyond them.


Speculative ethics Anticipatory bioethics Bioethics Gene editing Genetic engineering Regulation 



  1. 1.
    Weckert J (2007) Editorial. NanoEthics 1(1):1–2. CrossRefGoogle Scholar
  2. 2.
    Nordmann A (2007) If and then: a critique of speculative nanoethics. NanoEthics. 1(1):31–46. CrossRefGoogle Scholar
  3. 3.
    Collingridge D (1980) The social control of technology. St. Martin’s Press, New YorkGoogle Scholar
  4. 4.
    Agar N (2004) Liberal eugenics: in defence of human enhancement. Blackwell, MaldenCrossRefGoogle Scholar
  5. 5.
    Schick A (2017) Bioethics and the regulation/legitimation of the imagined future. In: Verschraegen G, Vandermoere F, BraeckmansL, Segaert B (eds.) Imagined futures in science, technology and society. Routledge, London, Ch. 2Google Scholar
  6. 6.
    Walters L (2012) Genetics and bioethics: how our thinking has changed since 1969. Theor Med Bioeth. 33(1):83–95. CrossRefGoogle Scholar
  7. 7.
    President’s Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research (1982). Splicing life: a report on the social and ethical issues of genetic engineering with human beings. Washington, DCGoogle Scholar
  8. 8.
    Juengst ET (1991) The human genome project and bioethics. Kennedy Inst Ethics J. 1(1):71–74CrossRefGoogle Scholar
  9. 9.
    Walters L (1991) Human gene therapy: ethics and public policy. Hum Gene Ther. 2(2):115–122CrossRefGoogle Scholar
  10. 10.
    Juengst ET (1991) Germ-line gene therapy: back to basics. J Med Philos. 16(6):587–592CrossRefGoogle Scholar
  11. 11.
    Parens E (2000) Enhancing human traits: ethical and social implications. Georgetown University Press, Washington, DCGoogle Scholar
  12. 12.
    Lenzi RN, Altevogt BM, Gostin LO (2014) Oversight and review of clinical gene transfer protocols: assessing the role of the recombinant DNA advisory committee. The National Academies Press, Washington, DCGoogle Scholar
  13. 13.
    Baltimore D, Berg P, Botchan M et al (2015) A prudent path forward for genomic engineering and germline gene modification. Science. 348(6230):36–38. CrossRefGoogle Scholar
  14. 14.
    Liang P, Xu Y, Zhang X, Ding C, Huang R, Zhang Z, Lv J, Xie X, Chen Y, Li Y, Sun Y, Bai Y, Songyang Z, Ma W, Zhou C, Huang J (2015) CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein Cell. 6(5):363–372. CrossRefGoogle Scholar
  15. 15.
    Organizing Committee for the International Summit on Human Gene Editing (2015) On human gene editing: international summit statement.. Accessed 17 Jan 2019
  16. 16.
    National Academy of Sciences, National Academy of Medicine Committee on Human Gene Editing (2017) Human genome editing: science, ethics, and governance. National Academies Press, Washington, D.C.
  17. 17.
    Kaiser J. U.S. panel gives yellow light to human embryo editing. Science. Accessed 29 Jan 2019
  18. 18.
    Juengst ET (2017) Crowdsourcing the moral limits of human gene editing? Hastings Cent Rep. 47(3):15–23. CrossRefGoogle Scholar
  19. 19.
    Evans JH (2012) The history and future of bioethics: a sociological view. Oxford University Press, New YorkGoogle Scholar
  20. 20.
    HFEA approval for new genome editing techniques. Francis Crick Institute. Accessed 24 Jan 2019
  21. 21.
    Servick K. First U.S. team to gene-edit human embryos revealed. Science. Accessed 24 Jan 2019
  22. 22.
    Regalado A. Years before CRISPR babies, this man was the first to edit human embryos. MIT Technology Review. Accessed 17 Jan 2019
  23. 23.
    Belluck P. How to stop rogue gene-editing of human embryos? The New York Times. Accessed 24 Jan 2019
  24. 24.
    Greely H. Of Science, CRISPR-Cas9, and Asilomar. Law Biosci Blog. April 2015. Accessed 29 Feb 2016
  25. 25.
    Evans JH (2002) Playing God? Human genetic engineering and the rationalization of public bioethical debate. University of Chicago Press, ChicagoGoogle Scholar
  26. 26.
    Juengst ET (2000) What does enhancement mean? In: Parens E (ed) Enhancing human traits. Georgetown University Press, Washington, DC, pp 29–47Google Scholar
  27. 27.
    Jasanoff S, Hurlbut JB (2018) A global observatory for gene editing. Nature. 555(7697):435. CrossRefGoogle Scholar
  28. 28.
    Next time, ask first: The affair of the gene-edited babies rumbles on. The Economist. 429(9122):82–83. Accessed 24 Jan 2019
  29. 29.
    Schick A (2014) Lessons for the future? Prophecy and policy in speculative bioethics. Michigan State UniversityGoogle Scholar

Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Polonsky LibraryVan Leer Jerusalem InstituteJerusalemIsrael

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