Advertisement

Der Nephrologe

, Volume 13, Issue 4, pp 270–272 | Cite as

Wie wird die Bildung von Erythropoietin gesteuert?

  • J. Fandrey
Wie funktioniert es?
  • 91 Downloads

How is the formation of erythropoietin controlled?

Notes

Interessenkonflikt

J. Fandrey gibt an, dass kein Interessenkonflikt besteht.

Literatur

  1. 1.
    Dame C, Fahnenstich H, Freitag P et al (1998) Erythropoietin mRNA expression in human fetal and neonatal tissue. Blood 92:3218–3225PubMedGoogle Scholar
  2. 2.
    Eschbach JW, Egrie JC, Downing MR et al (1987) Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial. N Engl J Med 316:73–78CrossRefPubMedGoogle Scholar
  3. 3.
    Fandrey J (2004) Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression. Am J Physiol Regul Integr Comp Physiol 286:R977–R988CrossRefPubMedGoogle Scholar
  4. 4.
    Haase VH (2010) Hypoxic regulation of erythropoiesis and iron metabolism. Am J Physiol Renal Physiol 299:F1–F13CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Haase VH (2017) Oxygen sensors as therapeutic targets in kidney disease. Nephrol Ther 13:S29–S34CrossRefPubMedGoogle Scholar
  6. 6.
    Ivan M, Kaelin WG (2017) The EGLN-HIF O2-sensing system: multiple inputs and feedbacks. Mol Cell 66:772–779CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Kaelin WG Jr, Ratcliffe PJ et al (2016) Pathways for oxygen regulation and homeostasis: the 2016 albert lasker basic medical research award. JAMA 316:1252–1253CrossRefPubMedGoogle Scholar
  8. 8.
    Maxwell PH, Eckardt K‑U (2016) HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond. Nat Rev Nephrol 12:157–168CrossRefPubMedGoogle Scholar
  9. 9.
    Schofield CJ, Ratcliffe PJ (2004) Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 5:343–354CrossRefPubMedGoogle Scholar
  10. 10.
    Semenza GL (2011) Oxygen sensing, homeostasis, and disease. N Engl J Med 365:537–547CrossRefPubMedGoogle Scholar

Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Institut für Physiologie, Universitätsklinikum EssenUniversität Duisburg-EssenEssenDeutschland

Personalised recommendations