Die Rolle der Gerüstproteine in der Regulation der Schlitzmembran

Wie relevant ist posttranslationale Modifikation?
Nephro molekular
  • 13 Downloads

The role of scaffolding proteins in the regulation of the slit

Is posttranslational modification relevant?

Notes

Interessenkonflikt

H. Schenk und M. Schiffer geben an, dass kein Interessenkonflikt besteht.

Literatur

  1. 1.
    Martin CE, Petersen KA, Aoudjit L, Tilak M, Eremina V, Hardy WR et al (2018) ShcA adaptor protein promotes nephrin endocytosis and is upregulated in proteinuric nephropathies. J Am Soc Nephrol 29(1):92–103PubMedGoogle Scholar
  2. 2.
    Dumont V, Tolvanen TA, Kuusela S, Wang H, Nyman TA, Lindfors S et al (2017) PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease. Faseb J 31(9):3978–3990CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    New LA, Martin CE, Scott RP, Platt MJ, Keyvani Chahi A, Stringer CD et al (2016) Nephrin tyrosine phosphorylation is required to stabilize and restore podocyte foot process architecture. J Am Soc Nephrol 27(8):2422–2435CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Teng B, Schroder P, Muller-Deile J, Schenk H, Staggs L, Tossidou I et al (2016) CIN85 deficiency prevents nephrin endocytosis and proteinuria in diabetes. Diabetes 65(12):3667–3679CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Tossidou I, Teng B, Drobot L, Meyer-Schwesinger C, Worthmann K, Haller H et al (2010) CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes. J Biol Chem 285(33):25285–25295CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Tossidou I, Himmelseher E, Teng B, Haller H, Schiffer M (2014) SUMOylation determines turnover and localization of nephrin at the plasma membrane. Kidney Int 86(6):1161–1173CrossRefPubMedGoogle Scholar
  7. 7.
    Schenk H, Muller-Deile J, Kinast M, Schiffer M (2017) Disease modeling in genetic kidney diseases: zebrafish. Cell Tissue Res 369(1):127–141CrossRefPubMedGoogle Scholar
  8. 8.
    Ha TS, Hong EJ, Han GD (2015) Diabetic conditions downregulate the expression of CD2AP in podocytes via PI3-K/Akt signalling. Diabetes Metab Res Rev 31(1):50–60CrossRefPubMedGoogle Scholar
  9. 9.
    Quack I, Woznowski M, Potthoff SA, Palmer R, Konigshausen E, Sivritas S et al (2011) PKC alpha mediates beta-arrestin2-dependent nephrin endocytosis in hyperglycemia. J Biol Chem 286(15):12959–12970CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Tossidou I, Teng B, Menne J, Shushakova N, Park JK, Becker JU et al (2010) Podocytic PKC-alpha is regulated in murine and human diabetes and mediates nephrin endocytosis. PLoS ONE 5(4):e10185CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Klinik für Nieren- und HochdruckerkrankungenMedizinische Hochschule HannoverHannoverDeutschland

Personalised recommendations