Wartelistenmanagement vor Nierentransplantation

Leitthema
  • 13 Downloads

Zusammenfassung

Lange Wartezeiten und ältere zu transplantierende Patienten beeinflussen die Wartelistenführung und -pflege vor Nierentransplantation in Deutschland. Der vorliegende Beitrag liefert auf der Basis von Auswertungen der aktuellen Literaturlage und verschiedener internationaler Leitlinien zum Wartelistenmanagement eine Zusammenstellung der aktuellen Anforderungen an das Wartelistenmanagement vor Nierentransplantation. Indikationen und Kontraindikationen zur Aufnahme auf die Nierentransplantationswarteliste werden vor dem Hintergrund der aktuellen demographischen und medizinischen Entwicklung zusammengestellt und kritisch diskutiert.

Schlüsselwörter

Nierentransplantation Wartelisten Kontraindikationen Kardiovaskuläre Voruntersuchungen Abklärungsalgorithmus 

Waiting listing management for renal transplantation

Abstract

Long waiting times and a growing population of older potential transplant recipients is a challenge in the management of waiting lists for renal transplantation in Germany. Based upon analysis of current publications and various international guidelines this article takes a current approach to waiting list management for renal transplantation and provides a critical review of the indications and contraindications for listing potential renal transplant recipients in view of current demographic and medical developments.

Keywords

Kidney transplantation Waiting lists Contraindications Cardiovascular work-up Evaluation algorithm 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

U. Eisenberger gibt an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

Literatur

  1. 1.
    DSO (2018) DSO Pressemitteilung vom 15.01.18. https://www.presseportal.de/pm/34285/3839273 Google Scholar
  2. 2.
    Jahresstatistiken Eurotransplant. eurotransplant.org
  3. 3.
    Bundesaerztekammer (Hrsg) (2013) Richtlinien zur Organtransplantation gem. § 16 Abs. 1 S. 1 Nrn. 2u. 5 TPG. http://www.bundesaerztekammer.de/fileadmin/user_upload/downloads/Niere_0912013.pdf Google Scholar
  4. 4.
    European Renal Best Practice Transplantation Guideline Development Group (2013) ERBP guideline on the management and evaluation of the kidney donor and recipient. Nephrol Dial Transplant 28(Suppl 2):ii1–71CrossRefGoogle Scholar
  5. 5.
    Heldal K, Leivestad T, Hartmann A, Svendsen MV, Lien BH, Midtvedt K (2008) Kidney transplantation in the elderly – the Norwegian experience. Nephrol Dial Transplant 23(3):1026–1031CrossRefPubMedGoogle Scholar
  6. 6.
    Knoll G, Cockfield S, Blydt-Hansen T et al (2005) Canadian Society of Transplantation consensus guidelines on eligibility for kidney transplantation. CMAJ 173(10):1181–1184CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Ortiz A, Covic A, Fliser D et al (2014) Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure. Lancet 383(9931):1831–1843CrossRefPubMedGoogle Scholar
  8. 8.
    Karthikeyan V, Ananthasubramaniam K (2009) Coronary risk assessment and management options in chronic kidney disease patients prior to kidney transplantation. Curr Cardiol Rev 5(3):177–186CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Jeloka TK, Ross H, Smith R et al (2007) Renal transplant outcome in high-cardiovascular risk recipients. Clin Transplant 21(5):609–614CrossRefPubMedGoogle Scholar
  10. 10.
    Winther S, Bottcher M, Jorgensen HS et al (2016) Coronary calcium score may replace cardiovascular risk factors as primary risk stratification tool before kidney transplantation. Transplantation 100(10):2177–2187CrossRefPubMedGoogle Scholar
  11. 11.
    Blankholm AD, Pedersen BG, Stausbol-Gron B et al (2015) Preoperative planning of renal transplantation: a comparison of non-contrast-enhanced ultrasonography, computed tomography, and magnetic resonance angiography with observations from surgery. Acta radiol 56(12):1527–1533CrossRefPubMedGoogle Scholar
  12. 12.
    Kasiske BL, Cangro CB, Hariharan S et al (2001) The evaluation of renal transplantation candidates: clinical practice guidelines. Am J Transplant 1(Suppl 2):3–95PubMedGoogle Scholar
  13. 13.
    Batabyal P, Chapman JR, Wong G, Craig JC, Tong A (2012) Clinical practice guidelines on wait-listing for kidney transplantation: consistent and equitable? Transplantation 94(7):703–713CrossRefPubMedGoogle Scholar
  14. 14.
    Penn I (1998) Occurrence of cancers in immunosuppressed organ transplant recipients. Clin Transpl 1998:147–158Google Scholar
  15. 15.
    Chapman JR, Sheil AG, Disney AP (2001) Recurrence of cancer after renal transplantation. Transplant Proc 33(1–2):1830–1831CrossRefPubMedGoogle Scholar
  16. 16.
    Penn I (1997) Evaluation of transplant candidates with pre-existing malignancies. Ann Transplant 2(4):14–17PubMedGoogle Scholar
  17. 17.
    Bunnapradist S, Danovitch GM (2007) Evaluation of adult kidney transplant candidates. Am J Kidney Dis 50(5):890–898CrossRefPubMedGoogle Scholar
  18. 18.
    Campbell S, Pilmore H, Gracey D et al (2013) KHA-CARI guideline: recipient assessment for transplantation. Nephrology 18(6):455–462CrossRefPubMedGoogle Scholar
  19. 19.
    Dudley C, Harden P (2011) Renal Association clinical practice guideline on the assessment of the potential kidney transplant recipient. Nephron Clin Pract 118(Suppl 1):c209–c224CrossRefPubMedGoogle Scholar
  20. 20.
    Kalble T, Lucan M, Nicita G et al (2005) EAU guidelines on renal transplantation. Eur Urol 47(2):156–166CrossRefPubMedGoogle Scholar
  21. 21.
    Kim SH, Lee SO, Park JB et al (2011) A prospective longitudinal study evaluating the usefulness of a T-cell-based assay for latent tuberculosis infection in kidney transplant recipients. Am J Transplant 11(9):1927–1935CrossRefPubMedGoogle Scholar
  22. 22.
    Bruchfeld A, Wilczek H, Elinder CG (2004) Hepatitis C infection, time in renal-replacement therapy, and outcome after kidney transplantation. Transplantation 78(5):745–750CrossRefPubMedGoogle Scholar
  23. 23.
    Chute DF, Chung RT, Sise ME (2018) Direct-acting antiviral therapy for hepatitis C virus infection in the kidney transplant recipient. Kidney Int 93(3):560–567CrossRefPubMedGoogle Scholar
  24. 24.
    Ridruejo E (2015) Antiviral treatment for chronic hepatitis B in renal transplant patients. World J Hepatol 7(2):189–203CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Glanton CW, Kao TC, Cruess D, Agodoa LY, Abbott KC (2003) Impact of renal transplantation on survival in end-stage renal disease patients with elevated body mass index. Kidney Int 63(2):647–653CrossRefPubMedGoogle Scholar
  26. 26.
    Krishnan N, Higgins R, Short A et al (2015) Kidney transplantation significantly improves patient and graft survival irrespective of BMI: a cohort study. Am J Transplant 15(9):2378–2386CrossRefPubMedGoogle Scholar
  27. 27.
    Hellemons ME, Sanders JS, Seelen MA et al (2015) Assessment of cotinine reveals a dose-dependent effect of smoking exposure on long-term outcomes after renal transplantation. Transplantation 99(9):1926–1932CrossRefPubMedGoogle Scholar
  28. 28.
    Fried LP, Tangen CM, Walston J et al (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56(3):M146–156CrossRefPubMedGoogle Scholar
  29. 29.
    McAdams-DeMarco MA, Law A, King E et al (2015) Frailty and mortality in kidney transplant recipients. Am J Transplant 15(1):149–154CrossRefPubMedGoogle Scholar
  30. 30.
    Dusseux E, Albano L, Fafin C et al (2015) A simple clinical tool to inform the decision-making process to refer elderly incident dialysis patients for kidney transplant evaluation. Kidney Int 88(1):121–129CrossRefPubMedGoogle Scholar
  31. 31.
    Patzer RE, Basu M, Larsen CP et al (2016) iChoose kidney: a clinical decision aid for kidney transplantation versus dialysis treatment. Transplantation 100(3):630–639CrossRefPubMedPubMedCentralGoogle Scholar
  32. 32.
    Oniscu GC, Brown H, Forsythe J (2005) lmpact of cadaveric renal transplantation on survival in patients listed for transplantation. J Am Soc Nephrol 16:1859–1865CrossRefPubMedGoogle Scholar
  33. 33.
    Lentine K et al (2012) Obesity and kidney transplant candidates: how big is too big for transplantation? Am J Nephrol 36:575–586.  https://doi.org/10.1159/000345476 CrossRefPubMedGoogle Scholar

Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Klinik für Nephrologie, Universitätsklinikum Essen, Medizinische FakultätUniversität Duisburg-EssenEssenDeutschland

Personalised recommendations