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Position-based modeling of lesion displacement in ultrasound-guided breast biopsy

  • Eleonora TagliabueEmail author
  • Diego Dall’Alba
  • Enrico Magnabosco
  • Chiara Tenga
  • Igor Peterlik
  • Paolo Fiorini
Original Article
  • 101 Downloads

Abstract

Purpose

Although ultrasound (US) images represent the most popular modality for guiding breast biopsy, malignant regions are often missed by sonography, thus preventing accurate lesion localization which is essential for a successful procedure. Biomechanical models can support the localization of suspicious areas identified on a preoperative image during US scanning since they are able to account for anatomical deformations resulting from US probe pressure. We propose a deformation model which relies on position-based dynamics (PBD) approach to predict the displacement of internal targets induced by probe interaction during US acquisition.

Methods

The PBD implementation available in NVIDIA FleX is exploited to create an anatomical model capable of deforming online. Simulation parameters are initialized on a calibration phantom under different levels of probe-induced deformations; then, they are fine-tuned by minimizing the localization error of a US–visible landmark of a realistic breast phantom. The updated model is used to estimate the displacement of other internal lesions due to probe-tissue interaction.

Results

The localization error obtained when applying the PBD model remains below 11 mm for all the tumors even for input displacements in the order of 30 mm. This proposed method obtains results aligned with FE models with faster computational performance, suitable for real-time applications. In addition, it outperforms rigid model used to track lesion position in US-guided breast biopsies, at least halving the localization error for all the displacement ranges considered.

Conclusion

Position-based dynamics approach has proved to be successful in modeling breast tissue deformations during US acquisition. Its stability, accuracy and real-time performance make such model suitable for tracking lesions displacement during US-guided breast biopsy.

Keywords

Biomechanical model Position-based dynamics Ultrasound-guided breast biopsy Ultrasound tracking 

Notes

Acknowledgements

This Project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement Nos. 742671 “ARS” and 688188 “MURAB”).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Supplementary material

Supplementary material 1 (mp4 5085 KB)

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Copyright information

© CARS 2019
corrected publication 2019

Authors and Affiliations

  1. 1.Department of Computer ScienceUniversity of VeronaVeronaItaly
  2. 2.INRIAStrasbourgFrance

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