Advertisement

Gray matter nuclei damage in acute carbon monoxide intoxication assessed in vivo using diffusion tensor MR imaging

  • Wenqian Jiang
  • Qingyu Wu
  • Chun Zhou
  • Ziru Zhao
  • Yongming TanEmail author
Neuroradiology
  • 41 Downloads

Abstract

Objective

To observe the structural changes of gray matter nuclei in patients with acute carbon monoxide intoxication by diffusion tensor imaging (DTI), quantify the degree of deep gray matter damage in the brain by adopting imaging technology and research the characteristics of the damage and its pertinence with memory and cognitive impairment.

Methods

Twenty-five patients with acute carbon monoxide intoxication and 25 healthy volunteers matched in sex and age were examined by routine head MRI and diffusion tensor imaging (DTI). Bilateral hippocampus, dater nucleus, thalamus, amygdala, globus pallidus and putamen were taken as regions of interest. The mean diffusion coefficient (MD), anisotropic fraction (FA) and appearance of deep gray matter nucleus in patients with acute carbon monoxide intoxication were analyzed. It found that the change of diffusion coefficient (ADC) and its clinical correlation with cognitive impairment were generated by carbon monoxide intoxication.

Results

Compared with the healthy control group, the FA values of bilateral globus pallidus, hippocampus, dater nucleus and putamen decreased, while the FA values of amygdala and thalamus had no statistical significance; the MD values and ADC values of hippocampus, globus pallidus and putamen increased, while the MD and ADC values of dater nucleus, thalamus and amygdala had no statistical significance, either.

Conclusion

DTI is capable of sensitively reflecting the damage of gray matter nuclei caused by acute carbon monoxide intoxication and quantifying the degree of hypoxic brain damage in a certain extent, and may be related to cognitive impairment.

Keywords

Acute carbon monoxide intoxication Gray matter nucleus Apparent diffusion coefficient Average diffusion coefficient Anisotropic fraction 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

This article does not contain any studies with human participants or animals performed by any of the authors.

References

  1. 1.
    Kuo SC et al (2018) Hyperbaric oxygen therapy and acute carbon monoxide poisoning. Hu Li Za Zhi 65(4):11–17PubMedGoogle Scholar
  2. 2.
    Yeh P et al (2009) Tract-based spatial statistics (TBSS) of diffusion tensor imaging data in alcohol dependence: Abnormalities of the motivational neurocircuitry. Psychiatry Res Neuroimaging 173(1):22–30CrossRefGoogle Scholar
  3. 3.
    Maximov II et al (2015) Statistical instability of TBSS analysis based on DTI fitting algorithm. J Neuroimaging 25(6):883–891CrossRefPubMedGoogle Scholar
  4. 4.
    Shenton ME et al (2018) Mild traumatic brain injury: is DTI ready for the courtroom? Int J Law Psychiatry 61(50):50–63CrossRefPubMedGoogle Scholar
  5. 5.
    Chou MC, Li JY, Lai PH (2019) Longitudinal white matter changes following carbon monoxide poisoning: a 9-month follow-up voxelwise diffusional kurtosis imaging study. AJNR Am J Neuroradiol 40:478–482PubMedGoogle Scholar
  6. 6.
    Bach M et al (2014) Methodological considerations on tract-based spatial statistics (TBSS). Neuroimage 100:358–369CrossRefPubMedGoogle Scholar
  7. 7.
    Alegiani AC et al (2017) Comprehensive analysis of early fractional anisotropy changes in acute ischemic stroke. PLoS ONE 12(11):e0188318CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Rahman MT et al (2013) A comparative study of magnetic resonance venography techniques for the evaluation of the internal jugular veins in multiple sclerosis patients. Magn Reson Imaging 31(10):1668–1676CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    O’Shea TM et al (2005) Magnetic resonance and ultrasound brain imaging in preterm infants. Early Hum Dev 81(3):263–271CrossRefPubMedGoogle Scholar
  10. 10.
    Zhang J et al (2013) Possible effects of iron deposition on the measurement of DTI metrics in deep gray matter nuclei: an in vitro and in vivo study. Neurosci Lett 551:47–52CrossRefPubMedGoogle Scholar
  11. 11.
    Han YY et al (2018) Relationship between neutrophil-to-lymphocyte ratio and myocardial injury induced by acute carbon monoxide poisoning. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 36(5):362–364PubMedGoogle Scholar
  12. 12.
    Yi-Zhan C, Jin-Sheng LI, Xing J (2002) Delayed neuronal death and memory deficit after acute carbon monoxide poisoning in rat. Chin J Crit Care Med 147:103–114Google Scholar
  13. 13.
    Xue L et al (2017) Effects of hyperbaric oxygen on hippocampal neuronal apoptosis in rats with acute carbon monoxide poisoning. Undersea Hyperb Med 44(2):121–131CrossRefPubMedGoogle Scholar
  14. 14.
    Ding G et al (2008) Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats. J Cereb Blood Flow Metab 28(8):1440–1448CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Schinazi VR et al (2013) Hippocampal size predicts rapid learning of a cognitive map in humans. Hippocampus 23(6):515–528CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Sward DG, Austin TW (2018) Hemiplegia and bilateral globus pallidus infarcts after carbon monoxide poisoning: case report. Undersea Hyperb Med 45(1):95–100CrossRefPubMedGoogle Scholar
  17. 17.
    Kim DM et al (2017) Acute carbon monoxide poisoning: MR imaging findings with clinical correlation. Diagn Interv Imaging 98(4):299–306CrossRefPubMedGoogle Scholar
  18. 18.
    Wang X et al (2016) MRI and clinical manifestations of delayed encephalopathy after carbon monoxide poisoning. Pak J Pharm Sci 29(6 Suppl):2317–2320PubMedGoogle Scholar
  19. 19.
    Geraldo AF et al (2014) Delayed leukoencephalopathy after acute carbon monoxide intoxication. J Radiol Case Rep 8(5):1–8PubMedPubMedCentralGoogle Scholar
  20. 20.
    Fujiwara S et al (2012) Detecting damaged regions of cerebral white matter in the subacute phase after carbon monoxide poisoning using voxel-based analysis with diffusion tensor imaging. Neuroradiology 54(7):681–689CrossRefPubMedGoogle Scholar

Copyright information

© Italian Society of Medical Radiology 2019

Authors and Affiliations

  1. 1.Department of RadiologyThe First Affiliated Hospital of Nanchang UniversityNanchangChina

Personalised recommendations