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Multistationarity and Bistability for Fewnomial Chemical Reaction Networks

  • Elisenda Feliu
  • Martin HelmerEmail author
Article

Abstract

Bistability and multistationarity are properties of reaction networks linked to switch-like responses and connected to cell memory and cell decision making. Determining whether and when a network exhibits bistability is a hard and open mathematical problem. One successful strategy consists of analyzing small networks and deducing that some of the properties are preserved upon passage to the full network. Motivated by this, we study chemical reaction networks with few chemical complexes. Under mass action kinetics, the steady states of these networks are described by fewnomial systems, that is polynomial systems having few distinct monomials. Such systems of polynomials are often studied in real algebraic geometry by the use of Gale dual systems. Using this Gale duality, we give precise conditions in terms of the reaction rate constants for the number and stability of the steady states of families of reaction networks with one non-flow reaction.

Keywords

Chemical reaction networks Multistationarity and bistability Fewnomial systems Gale duality Real algebraic geometry Steady states of dynamical systems 

Notes

Acknowledgements

This work was partially funded by the Independent Research Fund of Denmark.

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Copyright information

© Society for Mathematical Biology 2018

Authors and Affiliations

  1. 1.Department of Mathematical SciencesUniversity of CopenhagenCopenhagenDenmark

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