BI 853520, a FAK-Simile of Prior FAK Inhibitors?
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In this issue of Targeted Oncology, the BI 853520 investigators present three complementary studies of BI 853520 that investigate this drug in both Western and Eastern patient populations, as well as investigating the effects of food and drug formulation on drug absorption [1, 2, 3]. It is the latest in the field of similar compounds against focal adhesion kinase (FAK), a pre-clinically promising target for cancer therapy. FAK is a multifunctional cytoplasmic tyrosine kinase that has been shown to play an important role in the regulation of proliferation, metastasis, angiogenesis and tumour microenvironment signalling . Some of these effects are mediated through kinase-dependent signalling and others through kinase-independent signalling [1, 4]. Overexpression of FAK has been observed in multiple different malignancies and may contribute to tumour progression and aggressiveness . Pre-clinically, inhibition of FAK has been shown to inhibit tumour growth [4, 5]. Anti-cancer drugs...
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No external funding was used in the preparation of this article.
Conflict of interest
Rachael Chang Lee and Hui Gan declare that they have no conflicts of interest that might be relevant to the contents of this article.
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