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Dielectric properties of bones for the monitoring of osteoporosis

  • Bilal AminEmail author
  • Muhammad Adnan Elahi
  • Atif Shahzad
  • Emily Porter
  • Barry McDermott
  • Martin O’Halloran
Review Article

Abstract

Osteoporosis is one of the most common diseases that leads to bone fractures. Dual-energy X-ray absorptiometry is currently employed to measure the bone mineral density and to diagnose osteoporosis. Alternatively, the dielectric properties of bones are found to be influenced by bone mineral density; hence, dielectric properties of bones may potentially be used to diagnose osteoporosis. Microwave tomographic imaging is currently in development to potentially measure in vivo dielectric properties of bone. Therefore, the foci of this work are to summarize all available dielectric data of bone in the microwave frequency range and to analyze the confounders that may have resulted in variations in reported data. This study also compares the relationship between the dielectric properties and bone quality reported across different studies. The review suggests that variations exist in the dielectric properties of bone and the relationship between bone volume fraction and dielectric properties is in agreement across all studies. Conversely, the evidence of a relationship between bone mineral density and dielectric properties is inconsistent across the studies. This summary of dielectric data of bone along with a comparison of the relationship between the dielectric properties and bone quality will accelerate the development of microwave tomographic imaging devices for the monitoring of osteoporosis.

Graphical abstract

Keywords

Bones Osteoporosis Bone mineral density Dielectric properties Microwave imaging 

Notes

Funding information

The research leading to these results has received funding from the European Research Council under the European Union’s Horizon 2020 Programme/ ERC Grant Agreement BioElecPro no. 637780.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    US Department of Health and Human Services (2004) Bone health and osteoporosis: a report of the surgeon general. US Health Hum Serv 32:437–228.  https://doi.org/10.2165/00002018-200932030-00004 CrossRefGoogle Scholar
  2. 2.
    Laster AJ (2014) Dual-energy X-ray absorptiometry: overused, neglected, or just misunderstood? N C Med J 75:132–136Google Scholar
  3. 3.
    Office of the Surgeon General (US) (2004) Bone health and osteoporosis: A report of the surgeon general. Rockville (MD): Office of the Surgeon General (US). Available from: https://www.ncbi.nlm.nih.gov/books/NBK45513/. Accessed 24/01/2018
  4. 4.
    Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, Lindsay R, National Osteoporosis Foundation (2014) Clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int 25:2359–2381.  https://doi.org/10.1007/s00198-014-2794-2 CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Chakkalakal DA, Johnson MW, Harper RA, Katz JL (1980) Dielectric properties of fluid-saturated bone. IEEE Trans Biomed Eng BME-27:95–100.  https://doi.org/10.1109/TBME.1980.326713 CrossRefGoogle Scholar
  6. 6.
    Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A (2007) Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res 22:465–475.  https://doi.org/10.1359/jbmr.061113 CrossRefPubMedGoogle Scholar
  7. 7.
    Organization WH (2004) WHO scientific group on the assessment of osteoporosis at primary health care level. World Health Organ 359:5–7.  https://doi.org/10.1016/S0140-6736(02)08761-5 CrossRefGoogle Scholar
  8. 8.
    Lochmüller E-M, Müller R, Kuhn V, Lill CA, Eckstein F (2003) Can novel clinical densitometric techniques replace or improve DXA in predicting bone strength in osteoporosis at the hip and other skeletal sites? J Bone Miner Res 18:906–912.  https://doi.org/10.1359/jbmr.2003.18.5.906 CrossRefPubMedGoogle Scholar
  9. 9.
    Wilkie JR, Giger ML, Chinander MR, Vokes TJ, Li H, Dixon L, Jaros V (2004) Comparison of radiographic texture analysis from computed radiography and bone densitometry systems. Med Phys 31:882–891.  https://doi.org/10.1118/1.1650529 CrossRefPubMedGoogle Scholar
  10. 10.
    Meaney PM, Goodwin D, Golnabi AH, Zhou T, Pallone M, Geimer SD, Burke G, Paulsen KD (2012) Clinical microwave tomographic imaging of the calcaneus: a first-in-human case study of two subjects. IEEE Trans Biomed Eng 59:3304–3313.  https://doi.org/10.1109/TBME.2012.2209202 CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Irastorza RM, Blangino E, Carlevaro CM, Vericat F (2014) Modeling of the dielectric properties of trabecular bone samples at microwave frequency. Med Biol Eng Comput 52:439–447.  https://doi.org/10.1007/s11517-014-1145-y CrossRefPubMedGoogle Scholar
  12. 12.
    Nazarian A, Von Stechow D, Zurakowski D et al (2008) Bone volume fraction explains the variation in strength and stiffness of cancellous bone affected by metastatic cancer and osteoporosis. Calcif Tissue Int 83:368–379.  https://doi.org/10.1007/s00223-008-9174-x CrossRefPubMedGoogle Scholar
  13. 13.
    Irastorza R, Mayosky M, Grigera R, Vericat F (2011) Dielectric properties of natural and demineralized collagen bone matrix. IEEE Trans Dielectr Electr Insul 18:320–328.  https://doi.org/10.1109/TDEI.2011.5704524 CrossRefGoogle Scholar
  14. 14.
    Ivancich A, Grigera JR, Muravchik C (1992) Electric behaviour of natural and demineralized bones. Dielectric properties up to 1 GHz. J Biol Phys 18:281–295.  https://doi.org/10.1007/BF00419425 CrossRefGoogle Scholar
  15. 15.
    Meaney PM, Zhou T, Goodwin D, Golnabi A, Attardo EA, Paulsen KD (2012) Bone dielectric property variation as a function of mineralization at microwave frequencies. Int J Biomed Imaging 2012:1–9.  https://doi.org/10.1155/2012/649612 CrossRefGoogle Scholar
  16. 16.
    Sierpowska J, Töyräs J, Hakulinen MA, Saarakkala S, Jurvelin JS, Lappalainen R (2003) Electrical and dielectric properties of bovine trabecular bone—relationships with mechanical properties and mineral density. Phys Med Biol 48:775–786CrossRefGoogle Scholar
  17. 17.
    Porter E, OHalloran M (2017) Investigation of histology region in dielectric measurements of heterogeneous tissues. IEEE Trans Antennas Propag 65:1.  https://doi.org/10.1109/TAP.2017.2741026 CrossRefGoogle Scholar
  18. 18.
    Porter E, Coates M, Popović M (2016) An early clinical study of time-domain microwave radar for breast health monitoring. IEEE Trans Biomed Eng 63:530–539.  https://doi.org/10.1109/TBME.2015.2465867 CrossRefPubMedGoogle Scholar
  19. 19.
    Brace CL (2009) Radiofrequency and microwave ablation of the liver, lung, kidney, and bone: what are the differences? Curr Probl Diagn Radiol 38:135–143.  https://doi.org/10.1067/j.cpradiol.2007.10.001 CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Nguyen PT, Abbosh A, Crozier S (2015) Microwave hyperthermia for breast cancer treatment using electromagnetic and thermal focusing tested on realistic breast models and antenna arrays. IEEE Trans Antennas Propag 63:4426–4434.  https://doi.org/10.1109/TAP.2015.2463681 CrossRefGoogle Scholar
  21. 21.
    Schwan HP, Foster KR (1980) RF-field interactions with biological systems: electrical properties and biophysical mechanisms. Proc IEEE 68:104–113.  https://doi.org/10.1109/PROC.1980.11589 CrossRefGoogle Scholar
  22. 22.
    Gabriel S, Lau RW, Gabriel C (1996) The dielectric properties of biological tissues. 2. Measurements in the frequency range 10 Hz to 20 GHz. Phys Med Biol 41:2251–2269.  https://doi.org/10.1088/0031-9155/41/11/002 CrossRefPubMedGoogle Scholar
  23. 23.
    Salahuddin S, Porter E, Krewer F, O’Halloran M (2017) Optimised analytical models of the dielectric properties of biological tissue. Med Eng Phys 43:103–111.  https://doi.org/10.1016/j.medengphy.2017.01.017 CrossRefPubMedGoogle Scholar
  24. 24.
    Shahzad A, Sonja K, Jones M et al (2017) Investigation of the effect of dehydration on tissue dielectric properties in ex vivo measurements. Biomed Phys Eng Express 3:1–9CrossRefGoogle Scholar
  25. 25.
    Peyman A, Gabriel C, Grant EH et al (2009) Variation of the dielectric properties of tissues with age: the effect on the values of SAR in children when exposed to walkie-talkie devices. Phys Med Biol 54:227–241.  https://doi.org/10.1088/0031-9155/55/17/5249 CrossRefPubMedGoogle Scholar
  26. 26.
    Clarke B (2008) Normal bone anatomy and physiology. Clin J Am Soc Nephrol 3(Suppl 3):1–16.  https://doi.org/10.2215/CJN.04151206 CrossRefGoogle Scholar
  27. 27.
    Sierpowska J, Lammi MJ, Hakulinen MA, Jurvelin JS, Lappalainen R, Töyräs J (2007) Effect of human trabecular bone composition on its electrical properties. Med Eng Phys 29:845–852.  https://doi.org/10.1016/j.medengphy.2006.09.007 CrossRefPubMedGoogle Scholar
  28. 28.
    Haba Y, Wurm A, Köckerling M, Schick C, Mittelmeier W, Bader R (2017) Characterization of human cancellous and subchondral bone with respect to electro physical properties and bone mineral density by means of impedance spectroscopy. Med Eng Phys 45:34–41.  https://doi.org/10.1016/j.medengphy.2017.04.002 CrossRefPubMedGoogle Scholar
  29. 29.
    Kosterich JD, Foster KR, Pollack SR (1983) Dielectric permittivity and electrical conductivity of fluid saturated bone. IEEE Trans Biomed Eng 30:81–86.  https://doi.org/10.1109/TBME.1983.325201 CrossRefPubMedGoogle Scholar
  30. 30.
    De Mercato G, Garcia Sanchez FJ (1992) Correlation between low-frequency electric conductivity and permittivity in the diaphysis of bovine femoral bone. IEEE Trans Biomed Eng 39:523–526.  https://doi.org/10.1109/10.135546 CrossRefPubMedGoogle Scholar
  31. 31.
    Reddy GN, Saha S (1984) Electrical and dielectric properties of wet bone as a function of frequency. IEEE Trans Biomed Eng BME-31:296–303.  https://doi.org/10.1109/TBME.1984.325268 CrossRefGoogle Scholar
  32. 32.
    Saha S, Williams PA (1992) Electrical and dielectric properties of wet human cancellous bone as a function of frequency. IEEE Trans Biomed Eng 39:1298–1304.  https://doi.org/10.1109/TBME.1984.325268 CrossRefPubMedGoogle Scholar
  33. 33.
    Williams PA, Saha S (1996) The electrical and dielectric properties of human bone tissue and their relationship with density and bone mineral content. Ann Biomed Eng 24:222–233.  https://doi.org/10.1007/BF02667351 CrossRefPubMedGoogle Scholar
  34. 34.
    Liboff AR, Rinaldi RA, Lavine LS, Shamos MH (1975) On electrical conduction in living bone. Clin Orthop Relat Res 106:330–335CrossRefGoogle Scholar
  35. 35.
    Golnabi AH, Meaney PM, Geimer S et al (2011) Microwave tomography for bone imaging. Proc Int Symp Biomed Imaging 9:956–959.  https://doi.org/10.1109/ISBI.2011.5872561 CrossRefGoogle Scholar
  36. 36.
    Irastorza RM, Carlevaro CM, Vericat F (2013) Is there any information on micro-structure in microwave tomography of bone tissue? Med Eng Phys 35:1173–1180.  https://doi.org/10.1016/j.medengphy.2012.12.014 CrossRefPubMedGoogle Scholar

Copyright information

© International Federation for Medical and Biological Engineering 2018

Authors and Affiliations

  1. 1.Department of Electrical and Electronic EngineeringNational University of Ireland GalwayGalwayIreland
  2. 2.Translational Medical Device Lab, Lambe Institute for Translational Research & HRB Clinical Research FacilityUniversity Hospital GalwayGalwayIreland
  3. 3.School of MedicineNational University of Ireland GalwayGalwayIreland

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