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Frontiers in Biology

, Volume 13, Issue 4, pp 293–296 | Cite as

HspX protein as a candidate vaccine against Mycobacterium tuberculosis: an overview

  • Arshid Yousefi-Avarvand
  • Mohsen Tafaghodi
  • Saman Soleimanpour
  • Farzad Khademi
Review

Abstract

Background

Tuberculosis (TB) is a contagious infectious disease caused by Mycobacterium tuberculosis (Mtb). This disease with two million deaths per year has the highest mortality rate among bacterial infections. The only available vaccine against TB is BCG vaccine. BCG is an effective vaccine against TB in childhood, however, due to some limitations, has not proper efficiency in adults. Also, BCG cannot produce an adequately protective response against reactivation of latent infections.

Objective

In the present study we will review the most recent findings about contribution of HspX protein in the vaccines against tuberculosis.

Methods

Therefore, many attempts have been made to improve BCG or to find its replacement. Most of the subunit vaccines for TB in various phases of clinical trials were constructed as prophylactic vaccines using Mtb proteins expressed in the replicating stage. These vaccines might prevent active TB but not reactivation of latent tuberculosis infection (LTBI). A literature search was performed on various online databases (PubMed, Scopus, and Google Scholar) regarding the roles of HspX protein in tuberculosis vaccines.

Results

Ideal subunit post-exposure vaccines should target all forms of TB infection, including active symptomatic and dormant (latent) asymptomatic forms. Among these subunit vaccines, HspX is the most important latent phase antigen of M. tuberculosis with a strong immunological response. There are many studies that have evaluated the immunogenicity of this protein to improve TB vaccine.

Conclusion

According to the studies, HspX protein is a good candidate for development of subunit vaccines against TB infection.

Keywords

HspX protein Mycobacterium tuberculosis vaccine 

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Notes

Acknowledgements

The authors are grateful to our colleagues in Mashhad University of Medical Sciences for their sincerely cooperation.

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Copyright information

© Higher Education Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Arshid Yousefi-Avarvand
    • 1
    • 2
  • Mohsen Tafaghodi
    • 3
  • Saman Soleimanpour
    • 1
    • 2
    • 4
  • Farzad Khademi
    • 5
  1. 1.Antimicrobial Resistance Research Center, School of MedicineMashhad University of Medical SciencesMashhadIran
  2. 2.Department of Microbiology and Virology, School of MedicineMashhad University of Medical SciencesMashhadIran
  3. 3.Nanotechnology Research Center, School of PharmacyMashhad University of Medical SciencesMashhadIran
  4. 4.Reference Tuberculosis Laboratory of Northeast-IranMashhad University of Medical SciencesMashhadIran
  5. 5.Department of Microbiology, School of MedicineArdabil University of Medical SciencesArdabilIran

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