Applied Research in Quality of Life

, Volume 14, Issue 5, pp 1301–1313 | Cite as

Quality of Life Outcomes in Internet-Delivered (Space from Depression) Treatment for Depression

  • A. Enrique
  • J. Burke
  • D. RichardsEmail author
  • L. Timulak


Quality of Life (QoL) outcomes in interventions for depression are an area in the literature that has received little focus, particularly in trials relating to internet-delivered psychological interventions. Evaluating QoL outcomes are necessary to more completely understand if an intervention is successful in the treatment of depression, given that a decrease in negative symptoms in depression does not equate to synonymous increase in QoL. This secondary analysis study is aimed to examine the effects of an internet-delivered intervention for a mild to moderate depressed sample on QoL. 188 participants were randomly allocated to the Space from Depression intervention (n = 96) or a waiting-list group (n = 92). The intervention is an eight-module online cognitive-behavioural therapy intervention for depression. The trial had a duration of 8 weeks and the results were explored up to 3 months later. QoL was measured using the EuroQol-5D (EQ-5D) at different time points. The intervention produced positive effects in the global scores of QoL at post-treatment an these results were maintained at follow-up, although no differences between conditions were found. Analyses of the QoL dimensions showed a significant improvement on the Anxiety/depression dimension compared to controls, but no effects were found in other dimensions. The results suggest that internet-delivered interventions has the potential to produce changes in QoL. These results can potentially be understood by the lower impairments within a mild to moderate depressed sample. Further inferences about the sensitivity of the EQ-5D measure within this population are discussed in light of the findings.


Quality of life Internet-delivered interventions EQ-5D Depression 



This study was funded by SilverCloud Health.

Compliance with Ethical Standards

Conflict of Interest

Authors A, B & C are employees of SilverCloud health, developers of computerized psychological interventions for depression and anxiety, stress and comorbid long-term conditions. Author D declares that he has no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Nature B.V. and The International Society for Quality-of-Life Studies (ISQOLS) 2018

Authors and Affiliations

  • A. Enrique
    • 1
    • 2
  • J. Burke
    • 1
    • 2
  • D. Richards
    • 1
    • 2
    Email author
  • L. Timulak
    • 2
  1. 1.Cinical Research & InnovationSilverCloud HealthDublinIreland
  2. 2.E-mental Health Research Group, School of PsychologyUniversity of Dublin, Trinity CollegeDublinIreland

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