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Editor’s Commentary for Special Issue: “The Role of Macrophages in HIV Persistence”

  • Tricia H. BurdoEmail author
GUEST COMMENTARY
  • 39 Downloads

Abstract

Macrophages as reservoirs for persistent HIV infection has gained renewed importance, with an intense research focus dedicated to eradication strategies. Clearance of both latent and productive HIV from these important reservoirs is essential for successful eradication. This spe cial theme issue contains 11 papers, including 6 Invited Reviews, 1 Brief Report and 4 Original Articles, that focus on the various aspects of the macrophage as pertains to HIV persistence, latency and cure. These topics include: functional latency of macrophages and microglia, the link between peripheral monocytes and pathogenesis, macrophages as sources of HIV RNA and DNA in virally suppressed patients, brain imaging of neuroinflammation, macrophages as drug delivery vehicles, therapeutic strategies of infected macrophages for cure, and the role of drugs of abuse in enhancing macrophage viral persistence.

Keywords

HIV Macrophage Reservoir Latency 

Notes

Funding

Dr. Burdo is supported by the following NIH grants; R01 HL141132, P30 MH092177, U01 HL123336, R01 AI123001, R01 NR015738, R01 HL141045 and R01 MH118031.

Compliance with Ethical Standards

Conflict of Interest

The author declares no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NeuroscienceTemple University School of MedicinePhiladelphiaUSA

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